{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Pereira HABS"],"funding":["Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pubmed_abstract":["Fluoride (F) can induce changes in the expression of several liver proteins, most of them localized in the mitochondria and its effect is dose- and time-dependent. This study analyzed the effect of distinct F concentrations and exposure periods on the mitochondrial activity of complex I-III and II-III in the liver. Thirty-six 21-day-old male Wistar rats were divided into 2 groups (n = 18) according to the duration of the treatment (20 or 60 days). They were subdivided into 3 subgroups (n = 6) according to the concentration of F (0 mg/L, 15 mg/L or 50 mg/L). After the experimental periods, the animals were anesthetized, liver mitochondria were isolated and stored for activity analyses. The determination of complexes II-III and I-III was based on the reduction of cytochrome c<sup>3+</sup> to"],"journal":["Heliyon"],"pagination":["e06028"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7829207"],"repository":["biostudies-literature"],"pubmed_title":["Increase of complex I and reduction of complex II mitochondrial activity are possible adaptive effects provoked by fluoride exposure."],"pmcid":["PMC7829207"],"pubmed_authors":["Pereira FS","Pereira HABS","Araujo TT","Dionizio A","Iano FG","Trevizol JS","Faria Ximenes V","Buzalaf MAR"],"additional_accession":[]},"is_claimable":false,"name":"Increase of complex I and reduction of complex II mitochondrial activity are possible adaptive effects provoked by fluoride exposure.","description":"Fluoride (F) can induce changes in the expression of several liver proteins, most of them localized in the mitochondria and its effect is dose- and time-dependent. This study analyzed the effect of distinct F concentrations and exposure periods on the mitochondrial activity of complex I-III and II-III in the liver. Thirty-six 21-day-old male Wistar rats were divided into 2 groups (n = 18) according to the duration of the treatment (20 or 60 days). They were subdivided into 3 subgroups (n = 6) according to the concentration of F (0 mg/L, 15 mg/L or 50 mg/L). After the experimental periods, the animals were anesthetized, liver mitochondria were isolated and stored for activity analyses. The determination of complexes II-III and I-III was based on the reduction of cytochrome c<sup>3+</sup> to","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-04-28T22:53:39.896Z","creation":"2024-11-13T03:59:09.41Z"},"accession":"S-EPMC7829207","cross_references":{"pubmed":["33532647"],"doi":["10.1016/j.heliyon.2021.e06028"]}}