{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Oh KE"],"funding":["National Research Foundation of Korea grant funded by the Korean Government"],"pagination":["446"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7830106"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(2)"],"pubmed_abstract":["<i>Vitis amurensis</i> roots have been reported to have the potential for skin whitening through the evaluation of melanogenesis and tyrosinase inhibitory activities. In this study, <i>V. amurensis</i> roots were utilized to quickly select whitening ingredients using LC-Q-TOF-MS coupled with tyrosinase inhibitory assay, and to optimize the extraction process for use as a skin whitening functional material by response surface methodology. Results showed that <i>V. amurensis</i> roots exhibited tyrosinase inhibitory effects by two stilbene oligomers, ε-viniferin (<b>1</b>) and vitisin B (<b>2</b>), as predicted by LC-Q-TOF-MS coupled with bioassay. The optimal extraction conditions (methanol concentration 66%, solvent volume 140 mL, and extraction time 100 min) for skin whitening ingredients"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Characterization and Optimization of the Tyrosinase Inhibitory Activity of <i>Vitis amurensis</i> Root Using LC-Q-TOF-MS Coupled with a Bioassay and Response Surface Methodology."],"pmcid":["PMC7830106"],"funding_grant_id":["NRF-2016R1A6A1A03011325, NRF-2017R1A2B4003403 and NRF-2019R1A6A1A03031807"],"pubmed_authors":["Oh KE","Lee MK","Park B","Lee KY","Shin H"],"additional_accession":[]},"is_claimable":false,"name":"Characterization and Optimization of the Tyrosinase Inhibitory Activity of <i>Vitis amurensis</i> Root Using LC-Q-TOF-MS Coupled with a Bioassay and Response Surface Methodology.","description":"<i>Vitis amurensis</i> roots have been reported to have the potential for skin whitening through the evaluation of melanogenesis and tyrosinase inhibitory activities. In this study, <i>V. amurensis</i> roots were utilized to quickly select whitening ingredients using LC-Q-TOF-MS coupled with tyrosinase inhibitory assay, and to optimize the extraction process for use as a skin whitening functional material by response surface methodology. Results showed that <i>V. amurensis</i> roots exhibited tyrosinase inhibitory effects by two stilbene oligomers, ε-viniferin (<b>1</b>) and vitisin B (<b>2</b>), as predicted by LC-Q-TOF-MS coupled with bioassay. The optimal extraction conditions (methanol concentration 66%, solvent volume 140 mL, and extraction time 100 min) for skin whitening ingredients","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-05-04T23:51:00.235Z","creation":"2025-06-01T03:56:40.658Z"},"accession":"S-EPMC7830106","cross_references":{"pubmed":["33467011"],"doi":["10.3390/molecules26020446"]}}