biostudies-literatureDepommier CCanada Excellence Research Chairs, Government of CanadaFunds Baillet LatourCIHR185https://www.ebi.ac.uk/biostudies/studies/S-EPMC7832901biostudies-literatureUnknown10(1)<i>Akkermansia muciniphila</i> is considered as one of the next-generation beneficial bacteria in the context of obesity and associated metabolic disorders. Although a first proof-of-concept of its beneficial effects has been established in the context of metabolic syndrome in humans, mechanisms are not yet fully understood. This study aimed at deciphering whether the bacterium exerts its beneficial properties through the modulation of the endocannabinoidome (eCBome). Circulating levels of 25 endogenous endocannabinoid-related lipids were quantified by liquid chromatography with tandem mass spectrometry (LC-MS/MS) in the plasma of overweight or obese individuals before and after a 3 months intervention consisting of the daily ingestion of either alive or pasteurized <i>A. muciniphila</i>. CellsBeneficial Effects of <i>Akkermansia muciniphila</i> Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists.PMC7832901Grant for medical research 2015Gut Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND)Iannotti FAThissen JPMaiter DHermans MPFlamand NLoumaye AEverard Ade Vos WMDi Marzo VDepommier CVitale RMDruart CSilvestri CPelicaen RDelzenne NMCani PDfalseBeneficial Effects of <i>Akkermansia muciniphila</i> Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists.<i>Akkermansia muciniphila</i> is considered as one of the next-generation beneficial bacteria in the context of obesity and associated metabolic disorders. Although a first proof-of-concept of its beneficial effects has been established in the context of metabolic syndrome in humans, mechanisms are not yet fully understood. This study aimed at deciphering whether the bacterium exerts its beneficial properties through the modulation of the endocannabinoidome (eCBome). Circulating levels of 25 endogenous endocannabinoid-related lipids were quantified by liquid chromatography with tandem mass spectrometry (LC-MS/MS) in the plasma of overweight or obese individuals before and after a 3 months intervention consisting of the daily ingestion of either alive or pasteurized <i>A. muciniphila</i>. 2021-01-01T00:00:00Z2021 Jan2026-05-03T08:23:57.962Z2021-02-21T03:40:17ZS-EPMC78329013347782110.3390/cells10010185