{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Steiner F"],"funding":["Swiss National Science Foundation"],"pagination":["609234"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7835704"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["<b>Background:</b> Silent and overt ischemic brain lesions are common and associated with adverse outcome. Whether the CHA<sub>2</sub>DS<sub>2</sub>-VASc score and its components predict magnetic resonance imaging (MRI)-detected ischemic silent and overt brain lesions in patients with atrial fibrillation (AF) is unclear. <b>Methods:</b> In this cross-sectional analysis, patients with AF were enrolled in a multicenter cohort study in Switzerland. Outcomes were clinically overt, silent [in the absence of a history of stroke/transient ischemic attack (TIA)] and any MRI-detected ischemic brain lesions. Logistic regression analyses were performed to assess the relationship of the CHA<sub>2</sub>DS<sub>2</sub>-VASc score and its components with ischemic brain lesions. An adapted CHA<sub>2</sub>D"],"journal":["Frontiers in neurology"],"pubmed_title":["Association of the CHA<sub>2</sub>D(S<sub>2</sub>)-VASc Score and Its Components With Overt and Silent Ischemic Brain Lesions in Patients With Atrial Fibrillation."],"pmcid":["PMC7835704"],"funding_grant_id":["148474"],"pubmed_authors":["Meyre PB","Steiner F","Coslovsky M","Krisai P","Kuhne M","Conen D","Osswald S","Blum MR","Bonati LH","Aeschbacher S","Cussigh A","Cereda CW","Reichlin T","Wenger F","Swiss-AF Investigators","Roten L","Rodondi N","Sinnecker T","di Valentino M"],"additional_accession":[]},"is_claimable":false,"name":"Association of the CHA<sub>2</sub>D(S<sub>2</sub>)-VASc Score and Its Components With Overt and Silent Ischemic Brain Lesions in Patients With Atrial Fibrillation.","description":"<b>Background:</b> Silent and overt ischemic brain lesions are common and associated with adverse outcome. Whether the CHA<sub>2</sub>DS<sub>2</sub>-VASc score and its components predict magnetic resonance imaging (MRI)-detected ischemic silent and overt brain lesions in patients with atrial fibrillation (AF) is unclear. <b>Methods:</b> In this cross-sectional analysis, patients with AF were enrolled in a multicenter cohort study in Switzerland. Outcomes were clinically overt, silent [in the absence of a history of stroke/transient ischemic attack (TIA)] and any MRI-detected ischemic brain lesions. Logistic regression analyses were performed to assess the relationship of the CHA<sub>2</sub>DS<sub>2</sub>-VASc score and its components with ischemic brain lesions. An adapted CHA<sub>2</sub>D","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-29T08:23:55.521Z","creation":"2021-02-21T05:09:16Z"},"accession":"S-EPMC7835704","cross_references":{"pubmed":["33510705"],"doi":["10.3389/fneur.2020.609234"]}}