biostudies-literatureSteiner FSwiss National Science Foundation609234https://www.ebi.ac.uk/biostudies/studies/S-EPMC7835704biostudies-literatureUnknown11<b>Background:</b> Silent and overt ischemic brain lesions are common and associated with adverse outcome. Whether the CHA<sub>2</sub>DS<sub>2</sub>-VASc score and its components predict magnetic resonance imaging (MRI)-detected ischemic silent and overt brain lesions in patients with atrial fibrillation (AF) is unclear. <b>Methods:</b> In this cross-sectional analysis, patients with AF were enrolled in a multicenter cohort study in Switzerland. Outcomes were clinically overt, silent [in the absence of a history of stroke/transient ischemic attack (TIA)] and any MRI-detected ischemic brain lesions. Logistic regression analyses were performed to assess the relationship of the CHA<sub>2</sub>DS<sub>2</sub>-VASc score and its components with ischemic brain lesions. An adapted CHA<sub>2</sub>DFrontiers in neurologyAssociation of the CHA<sub>2</sub>D(S<sub>2</sub>)-VASc Score and Its Components With Overt and Silent Ischemic Brain Lesions in Patients With Atrial Fibrillation.PMC7835704148474Meyre PBSteiner FCoslovsky MKrisai PKuhne MConen DOsswald SBlum MRBonati LHAeschbacher SCussigh ACereda CWReichlin TWenger FSwiss-AF InvestigatorsRoten LRodondi NSinnecker Tdi Valentino MfalseAssociation of the CHA<sub>2</sub>D(S<sub>2</sub>)-VASc Score and Its Components With Overt and Silent Ischemic Brain Lesions in Patients With Atrial Fibrillation.<b>Background:</b> Silent and overt ischemic brain lesions are common and associated with adverse outcome. Whether the CHA<sub>2</sub>DS<sub>2</sub>-VASc score and its components predict magnetic resonance imaging (MRI)-detected ischemic silent and overt brain lesions in patients with atrial fibrillation (AF) is unclear. <b>Methods:</b> In this cross-sectional analysis, patients with AF were enrolled in a multicenter cohort study in Switzerland. Outcomes were clinically overt, silent [in the absence of a history of stroke/transient ischemic attack (TIA)] and any MRI-detected ischemic brain lesions. Logistic regression analyses were performed to assess the relationship of the CHA<sub>2</sub>DS<sub>2</sub>-VASc score and its components with ischemic brain lesions. An adapted CHA<sub>2</sub>D2020-01-01T00:00:00Z20202026-04-29T08:23:55.521Z2021-02-21T05:09:16ZS-EPMC78357043351070510.3389/fneur.2020.609234