{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(2)"],"submitter":["Vessella G"],"pubmed_abstract":["Controlling chondroitin sulfates (CSs) biological functions to exploit their interesting potential biomedical applications requires a comprehensive understanding of how the specific sulfate distribution along the polysaccharide backbone can impact in their biological activities, a still challenging issue. To this aim, herein, we have applied an \"holistic approach\" recently developed by us to look globally how a specific sulfate distribution within CS disaccharide epitopes can direct the binding of these polysaccharides to growth factors. To do this, we have analyzed several polysaccharides of marine origin and semi-synthetic polysaccharides, the latter to isolate the structure-activity relationships of their rare, and even unnatural, sulfated disaccharide epitopes. SPR studies revealed tha"],"journal":["Polymers"],"pagination":["313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7835997"],"repository":["biostudies-literature"],"pubmed_title":["Deciphering Structural Determinants in Chondroitin Sulfate Binding to FGF-2: Paving the Way to Enhanced Predictability of their Biological Functions."],"pmcid":["PMC7835997"],"pubmed_authors":["Fernandez-Mayoralas A","Valcarcel J","Vazquez JA","Monterrey DT","Bedini E","Revuelta J","Bastida A","Garcia-Junceda E","Vessella G","Lagartera L"],"additional_accession":[]},"is_claimable":false,"name":"Deciphering Structural Determinants in Chondroitin Sulfate Binding to FGF-2: Paving the Way to Enhanced Predictability of their Biological Functions.","description":"Controlling chondroitin sulfates (CSs) biological functions to exploit their interesting potential biomedical applications requires a comprehensive understanding of how the specific sulfate distribution along the polysaccharide backbone can impact in their biological activities, a still challenging issue. To this aim, herein, we have applied an \"holistic approach\" recently developed by us to look globally how a specific sulfate distribution within CS disaccharide epitopes can direct the binding of these polysaccharides to growth factors. To do this, we have analyzed several polysaccharides of marine origin and semi-synthetic polysaccharides, the latter to isolate the structure-activity relationships of their rare, and even unnatural, sulfated disaccharide epitopes. SPR studies revealed tha","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-04-27T02:08:55.209Z","creation":"2025-04-06T18:25:23.411Z"},"accession":"S-EPMC7835997","cross_references":{"pubmed":["33478164"],"doi":["10.3390/polym13020313"]}}