{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou X"],"funding":["NIDDK NIH HHS","NIA NIH HHS","NIAID NIH HHS","NCI NIH HHS","National Institutes of Health"],"pagination":["108601"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7839063"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(1)"],"pubmed_abstract":["Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity."],"journal":["Cell reports"],"pubmed_title":["Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity."],"pmcid":["PMC7839063"],"funding_grant_id":["R01 CA225680","R01 AI147394","R01 AI112844","P30 CA015083","R01 AG047156","R01 DK053189","U24 DK100469"],"pubmed_authors":["Li Y","Bernlohr DA","Copland JA","Li C","Shapiro VS","Hitosugi T","Zhu X","Zeng H","Zhou X","Sun J","Ye Z"],"additional_accession":[]},"is_claimable":false,"name":"Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity.","description":"Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-05-05T06:51:29.364Z","creation":"2025-04-06T18:16:02.723Z"},"accession":"S-EPMC7839063","cross_references":{"pubmed":["33406440"],"doi":["10.1016/j.celrep.2020.108601"]}}