{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["National Natural Science Foundation of China"],"pagination":["571106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7840487"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Chronic heart failure (CHF) is a common cardiovascular disease with high mortality and a poor prognosis, which places heavy burdens upon society and families. Traditional Chinese medicine (TCM) has been used extensively as complementary treatment for CHF. <i>Guanxinshutong</i> (GXST) capsules are used commonly for the treatment of coronary heart disease (CHD). Experimental research and small-sample clinical trials have shown that GXST can attenuate CHF. However, the effects of GXST as complementary medicine in CHF treatment lack high-quality clinical evidence. We have designed a multicenter, randomized, double-blind, placebo-controlled clinical trial that explores the efficacy and safety of using GXST compared with placebo for patients with CHF with reduced left ventricular ejection fracti"],"journal":["Frontiers in pharmacology"],"pubmed_title":["Effects of <i>Guanxinshutong</i> Capsules as Complementary Treatment in Patients With Chronic Heart Failure: Study Protocol for a Randomized Controlled Trial."],"pmcid":["PMC7840487"],"funding_grant_id":["81630105"],"pubmed_authors":["Yang J","Yu L","Pan Y","Dou L","Li C","Zhou P","Chen J","Fu W","Zhang L","Xu J","Huang S","He Y","Wan H","Wang Y","Zhou H","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Effects of <i>Guanxinshutong</i> Capsules as Complementary Treatment in Patients With Chronic Heart Failure: Study Protocol for a Randomized Controlled Trial.","description":"Chronic heart failure (CHF) is a common cardiovascular disease with high mortality and a poor prognosis, which places heavy burdens upon society and families. Traditional Chinese medicine (TCM) has been used extensively as complementary treatment for CHF. <i>Guanxinshutong</i> (GXST) capsules are used commonly for the treatment of coronary heart disease (CHD). Experimental research and small-sample clinical trials have shown that GXST can attenuate CHF. However, the effects of GXST as complementary medicine in CHF treatment lack high-quality clinical evidence. We have designed a multicenter, randomized, double-blind, placebo-controlled clinical trial that explores the efficacy and safety of using GXST compared with placebo for patients with CHF with reduced left ventricular ejection fracti","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-06-03T19:26:09.156Z","creation":"2026-04-30T03:11:58.47Z"},"accession":"S-EPMC7840487","cross_references":{"pubmed":["33519434"],"doi":["10.3389/fphar.2020.571106"]}}