biostudies-literatureWang YNational Natural Science Foundation of China571106https://www.ebi.ac.uk/biostudies/studies/S-EPMC7840487biostudies-literatureUnknown11Chronic heart failure (CHF) is a common cardiovascular disease with high mortality and a poor prognosis, which places heavy burdens upon society and families. Traditional Chinese medicine (TCM) has been used extensively as complementary treatment for CHF. <i>Guanxinshutong</i> (GXST) capsules are used commonly for the treatment of coronary heart disease (CHD). Experimental research and small-sample clinical trials have shown that GXST can attenuate CHF. However, the effects of GXST as complementary medicine in CHF treatment lack high-quality clinical evidence. We have designed a multicenter, randomized, double-blind, placebo-controlled clinical trial that explores the efficacy and safety of using GXST compared with placebo for patients with CHF with reduced left ventricular ejection fractiFrontiers in pharmacologyEffects of <i>Guanxinshutong</i> Capsules as Complementary Treatment in Patients With Chronic Heart Failure: Study Protocol for a Randomized Controlled Trial.PMC784048781630105Yang JYu LPan YDou LLi CZhou PChen JFu WZhang LXu JHuang SHe YWan HWang YZhou HXu YfalseEffects of <i>Guanxinshutong</i> Capsules as Complementary Treatment in Patients With Chronic Heart Failure: Study Protocol for a Randomized Controlled Trial.Chronic heart failure (CHF) is a common cardiovascular disease with high mortality and a poor prognosis, which places heavy burdens upon society and families. Traditional Chinese medicine (TCM) has been used extensively as complementary treatment for CHF. <i>Guanxinshutong</i> (GXST) capsules are used commonly for the treatment of coronary heart disease (CHD). Experimental research and small-sample clinical trials have shown that GXST can attenuate CHF. However, the effects of GXST as complementary medicine in CHF treatment lack high-quality clinical evidence. We have designed a multicenter, randomized, double-blind, placebo-controlled clinical trial that explores the efficacy and safety of using GXST compared with placebo for patients with CHF with reduced left ventricular ejection fracti2020-01-01T00:00:00Z20202026-06-03T19:26:09.156Z2026-04-30T03:11:58.47ZS-EPMC78404873351943410.3389/fphar.2020.571106