{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Yuan C"],"pubmed_abstract":["<h4>Objective</h4>Previous studies have shown that high glucose (HG) induces endothelial cell (EC) damage via endothelial-to-mesenchymal transition (EndMT). Although the underlying mechanisms are still unclear, recent studies have demonstrated the role of calcium-sensing receptor (CaSR) in mediating EC damage. Therefore, the aim of our study was to investigate whether CaSR mediates HG-induced EndMT and to determine the underlying mechanism.<h4>Methods</h4>Bioinformatics analysis of microarray profiles (GSE30780) and protein-protein interaction (PPI) analyses were performed to select the hub genes. As for <i>in vitro</i> research, the human aortic ECs (HAECs) were exposed to HG to induce EndMT. The expression of CaSR and β-catenin was determined, as well as their effects on EndMT (endotheli"],"journal":["Frontiers in physiology"],"pagination":["629542"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7844313"],"repository":["biostudies-literature"],"pubmed_title":["Calcium-Sensing Receptor Participates in High Glucose-Induced EndMT in Primary Human Aortic Endothelial Cells."],"pmcid":["PMC7844313"],"pubmed_authors":["Yang X","Yuan C","Ni L","Zhang C","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Calcium-Sensing Receptor Participates in High Glucose-Induced EndMT in Primary Human Aortic Endothelial Cells.","description":"<h4>Objective</h4>Previous studies have shown that high glucose (HG) induces endothelial cell (EC) damage via endothelial-to-mesenchymal transition (EndMT). Although the underlying mechanisms are still unclear, recent studies have demonstrated the role of calcium-sensing receptor (CaSR) in mediating EC damage. Therefore, the aim of our study was to investigate whether CaSR mediates HG-induced EndMT and to determine the underlying mechanism.<h4>Methods</h4>Bioinformatics analysis of microarray profiles (GSE30780) and protein-protein interaction (PPI) analyses were performed to select the hub genes. As for <i>in vitro</i> research, the human aortic ECs (HAECs) were exposed to HG to induce EndMT. The expression of CaSR and β-catenin was determined, as well as their effects on EndMT (endotheli","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-08T02:28:14.474Z","creation":"2021-02-21T05:27:07Z"},"accession":"S-EPMC7844313","cross_references":{"pubmed":["33519531"],"doi":["10.3389/fphys.2020.629542"]}}