{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Xiao M"],"pubmed_abstract":["<h4>Objective</h4>Gastric cancer is a potential malignant tumor. Extensive research has shown that apoptosis and autophagy are important mechanisms of cancer pathogenesis. This study aimed to explore the role and mechanism of TDB in apoptosis and autophagy in MGC-803 cells.<h4>Methods</h4>In cell experiments, the proliferation, apoptosis and autophagy of MGC-803 cells were evaluated by the MTT assay, TUNEL, flow cytometry, MDC, and TEM. Through molecular experiments, the TDB-induced apoptosis and autophagy effects were evaluated by examining the levels of Cleaved-PARP/PARP, Cleaved-caspase3/procaspase3, Beclin-1, p62 and the ratio of LC3-II/LC3-I. At the animal level, the anti-tumor effect of TDB <i>in vivo</i> was evaluated by assessing tumor volume and bioluminescence value.<h4>Results</"],"journal":["American journal of translational research"],"pagination":["73-87"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7847516"],"repository":["biostudies-literature"],"pubmed_title":["Compound TDB (Tricyclic decyl benzoxazole) induces autophagy-dependent apoptosis in the gastric cancer cell line MGC-803 by regulating PI3K/AKT/mTOR."],"pmcid":["PMC7847516"],"pubmed_authors":["Yang Z","Xiao M","Lin C","Huang Y","Fu J","Tian S"],"additional_accession":[]},"is_claimable":false,"name":"Compound TDB (Tricyclic decyl benzoxazole) induces autophagy-dependent apoptosis in the gastric cancer cell line MGC-803 by regulating PI3K/AKT/mTOR.","description":"<h4>Objective</h4>Gastric cancer is a potential malignant tumor. Extensive research has shown that apoptosis and autophagy are important mechanisms of cancer pathogenesis. This study aimed to explore the role and mechanism of TDB in apoptosis and autophagy in MGC-803 cells.<h4>Methods</h4>In cell experiments, the proliferation, apoptosis and autophagy of MGC-803 cells were evaluated by the MTT assay, TUNEL, flow cytometry, MDC, and TEM. Through molecular experiments, the TDB-induced apoptosis and autophagy effects were evaluated by examining the levels of Cleaved-PARP/PARP, Cleaved-caspase3/procaspase3, Beclin-1, p62 and the ratio of LC3-II/LC3-I. At the animal level, the anti-tumor effect of TDB <i>in vivo</i> was evaluated by assessing tumor volume and bioluminescence value.<h4>Results</","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T18:45:30.669Z","creation":"2025-04-04T18:45:30.669Z"},"accession":"S-EPMC7847516","cross_references":{"pubmed":["33527009"]}}