biostudies-literatureUnknown8He YAlpinia <i>oxyphylla</i> Miq. (AOM) is a medicinal herb for improving cognitive functions in traditional Chinese medicine for poststroke treatment, but its efficacies and underlying mechanisms remain unknown. In the present study, we tested the hypothesis that AOM could induce adult hippocampal neurogenesis and improve poststroke cognitive impairment <i>via</i> inducing brain-derived neurotrophic factor (BDNF) signaling pathway. In order to test the hypothesis, we performed both <i>in vivo</i> rat experiments using transient middle cerebral artery occlusion (MCAO) model and <i>in vitro</i> neural stem cell (NSC) experiments using oxygen-glucose deprivation plus reoxygenation. First, AOM treatment significantly up-regulated the expression of BDNF, tropomycin receptor kinase B (TrkB), and phFrontiers in cell and developmental biology577790https://www.ebi.ac.uk/biostudies/studies/S-EPMC7849625biostudies-literature<i>Alpinia oxyphylla</i> Miq. and Its Active Compound <i>P</i>-Coumaric Acid Promote Brain-Derived Neurotrophic Factor Signaling for Inducing Hippocampal Neurogenesis and Improving Post-cerebral Ischemic Spatial Cognitive Functions.PMC7849625Gu BShen JHe YTsoi BPeng CChen SQi SWang Zfalse<i>Alpinia oxyphylla</i> Miq. and Its Active Compound <i>P</i>-Coumaric Acid Promote Brain-Derived Neurotrophic Factor Signaling for Inducing Hippocampal Neurogenesis and Improving Post-cerebral Ischemic Spatial Cognitive Functions.Alpinia <i>oxyphylla</i> Miq. (AOM) is a medicinal herb for improving cognitive functions in traditional Chinese medicine for poststroke treatment, but its efficacies and underlying mechanisms remain unknown. In the present study, we tested the hypothesis that AOM could induce adult hippocampal neurogenesis and improve poststroke cognitive impairment <i>via</i> inducing brain-derived neurotrophic factor (BDNF) signaling pathway. In order to test the hypothesis, we performed both <i>in vivo</i> rat experiments using transient middle cerebral artery occlusion (MCAO) model and <i>in vitro</i> neural stem cell (NSC) experiments using oxygen-glucose deprivation plus reoxygenation. First, AOM treatment significantly up-regulated the expression of BDNF, tropomycin receptor kinase B (TrkB), and ph2020-01-01T00:00:00Z20202025-04-19T03:20:19.368Z2021-02-21T06:03:27ZS-EPMC78496253353729710.3389/fcell.2020.577790