{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li L"],"funding":["NIEHS NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health","NIGMS NIH HHS"],"pagination":["161-168"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7854983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(2)"],"pubmed_abstract":["The DNA guanine quadruplexes (G4) play important roles in multiple cellular processes, including DNA replication, transcription and maintenance of genome stability. Here, we showed that Yin and Yang 1 (YY1) can bind directly to G4 structures. ChIP-seq results revealed that YY1-binding sites overlap extensively with G4 structure loci in chromatin. We also observed that the dimerization of YY1 and its binding with G4 structures contribute to YY1-mediated long-range DNA looping. Displacement of YY1 from G4 structure sites disrupts substantially the YY1-mediated DNA looping. Moreover, treatment with G4-stabilizing ligands modulates the expression of not only those genes with G4 structures in their promoters, but also those associated with distal G4 structures that are brought to close proximit"],"journal":["Nature chemical biology"],"pubmed_title":["YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression."],"pmcid":["PMC7854983"],"funding_grant_id":["R35 ES031707 and R35 GM119721","R35 ES031707","R35 GM119721","T32 ES018827"],"pubmed_authors":["Ren W","Wang MY","Huang M","Gao Z","Miao W","Wang Y","Li L","Williams P","Song J"],"additional_accession":[]},"is_claimable":false,"name":"YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression.","description":"The DNA guanine quadruplexes (G4) play important roles in multiple cellular processes, including DNA replication, transcription and maintenance of genome stability. Here, we showed that Yin and Yang 1 (YY1) can bind directly to G4 structures. ChIP-seq results revealed that YY1-binding sites overlap extensively with G4 structure loci in chromatin. We also observed that the dimerization of YY1 and its binding with G4 structures contribute to YY1-mediated long-range DNA looping. Displacement of YY1 from G4 structure sites disrupts substantially the YY1-mediated DNA looping. Moreover, treatment with G4-stabilizing ligands modulates the expression of not only those genes with G4 structures in their promoters, but also those associated with distal G4 structures that are brought to close proximit","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2026-05-09T09:48:03.34Z","creation":"2025-04-03T21:31:16.232Z"},"accession":"S-EPMC7854983","cross_references":{"pubmed":["33199912"],"doi":["10.1038/s41589-020-00695-1"]}}