{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hersh J"],"funding":["NIA NIH HHS","NINDS NIH HHS","National Institutes of Health","Cancer Prevention and Research Institute of Texas"],"pagination":["577455"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7856103"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["351"],"pubmed_abstract":["We determined that T-cell astrocyte interaction modulates interleukin-10 (IL-10) production from both cell types. The impact of IL-10 on astrocytes was compared to IL-10 generated from T-cell-astrocyte interactions in vitro. We demonstrated that T-cells directly interact with astrocytes to upregulate gene expression and secretion of IL-10, confirmed by elevated STAT3p/STAT3 expression in astrocytes. IL-10 increased astrocytes proliferation. In addition, IL-10 treatment and CD4+ co-culture shifts primary astrocytes toward a more energetic phenotype. These findings indicate that direct interaction of CD4+ T-cells with astrocytes, activated the IL-10 anti-inflammatory pathway, altering astrocyte phenotype, metabolism, and proliferation."],"journal":["Journal of neuroimmunology"],"pubmed_title":["Modulation of astrocyte phenotype in response to T-cell interaction."],"pmcid":["PMC7856103"],"funding_grant_id":["T32 AG020494","RF1 NS109583","R01 NS088596"],"pubmed_authors":["Hersh J","Prah J","Liu R","Yang SH","Winters A"],"additional_accession":[]},"is_claimable":false,"name":"Modulation of astrocyte phenotype in response to T-cell interaction.","description":"We determined that T-cell astrocyte interaction modulates interleukin-10 (IL-10) production from both cell types. The impact of IL-10 on astrocytes was compared to IL-10 generated from T-cell-astrocyte interactions in vitro. We demonstrated that T-cells directly interact with astrocytes to upregulate gene expression and secretion of IL-10, confirmed by elevated STAT3p/STAT3 expression in astrocytes. IL-10 increased astrocytes proliferation. In addition, IL-10 treatment and CD4+ co-culture shifts primary astrocytes toward a more energetic phenotype. These findings indicate that direct interaction of CD4+ T-cells with astrocytes, activated the IL-10 anti-inflammatory pathway, altering astrocyte phenotype, metabolism, and proliferation.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-04T02:25:16.868Z","creation":"2025-04-04T02:25:16.868Z"},"accession":"S-EPMC7856103","cross_references":{"pubmed":["33370671"],"doi":["10.1016/j.jneuroim.2020.577455"]}}