{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Fang H"],"funding":["Natural Science Foundation of Hunan Province"],"pubmed_abstract":["Schistosomiasis has been a fatal obstinate disease that threatens global human health, resulting in the granulomatous inflammation and liver fibrosis. <b>Objective:</b>The aim of this study was to evaluate the therapeutic effects and mechanisms of hydroxyasiaticoside combined with praziquantel in the treatment of schistosomiasis-induced liver fibrosis. <b>Methods:</b>Mice were randomly distributed into four experimental groups: normal control group, model group, praziquantel group, praziquantel + hydroxyasiaticoside group. Except for the normal control group, they were infected with <i>Schistosomia cercariae</i> through the abdominal skin to induce liver fibrosis. In the intervention group, mice were administered with the respective drugs by gavage after 8 weeks of infection. At the end of"],"journal":["Frontiers in bioengineering and biotechnology"],"pagination":["613784"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7862569"],"repository":["biostudies-literature"],"pubmed_title":["<i>In vivo</i> Therapeutic Effects and Mechanisms of Hydroxyasiaticoside Combined With Praziquantel in the Treatment of Schistosomiasis Induced Hepatic Fibrosis."],"pmcid":["PMC7862569"],"pubmed_authors":["Fang H","Yu L","Guo W","Zhang X","You D","Peng N","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"<i>In vivo</i> Therapeutic Effects and Mechanisms of Hydroxyasiaticoside Combined With Praziquantel in the Treatment of Schistosomiasis Induced Hepatic Fibrosis.","description":"Schistosomiasis has been a fatal obstinate disease that threatens global human health, resulting in the granulomatous inflammation and liver fibrosis. <b>Objective:</b>The aim of this study was to evaluate the therapeutic effects and mechanisms of hydroxyasiaticoside combined with praziquantel in the treatment of schistosomiasis-induced liver fibrosis. <b>Methods:</b>Mice were randomly distributed into four experimental groups: normal control group, model group, praziquantel group, praziquantel + hydroxyasiaticoside group. Except for the normal control group, they were infected with <i>Schistosomia cercariae</i> through the abdominal skin to induce liver fibrosis. In the intervention group, mice were administered with the respective drugs by gavage after 8 weeks of infection. At the end of","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-04T22:03:53.375Z","creation":"2021-02-21T07:23:04Z"},"accession":"S-EPMC7862569","cross_references":{"pubmed":["33553120"],"doi":["10.3389/fbioe.2020.613784"]}}