biostudies-literatureUnknown8Fang HNatural Science Foundation of Hunan ProvinceSchistosomiasis has been a fatal obstinate disease that threatens global human health, resulting in the granulomatous inflammation and liver fibrosis. <b>Objective:</b>The aim of this study was to evaluate the therapeutic effects and mechanisms of hydroxyasiaticoside combined with praziquantel in the treatment of schistosomiasis-induced liver fibrosis. <b>Methods:</b>Mice were randomly distributed into four experimental groups: normal control group, model group, praziquantel group, praziquantel + hydroxyasiaticoside group. Except for the normal control group, they were infected with <i>Schistosomia cercariae</i> through the abdominal skin to induce liver fibrosis. In the intervention group, mice were administered with the respective drugs by gavage after 8 weeks of infection. At the end ofFrontiers in bioengineering and biotechnology613784https://www.ebi.ac.uk/biostudies/studies/S-EPMC7862569biostudies-literature<i>In vivo</i> Therapeutic Effects and Mechanisms of Hydroxyasiaticoside Combined With Praziquantel in the Treatment of Schistosomiasis Induced Hepatic Fibrosis.PMC7862569Fang HYu LGuo WZhang XYou DPeng NWang Jfalse<i>In vivo</i> Therapeutic Effects and Mechanisms of Hydroxyasiaticoside Combined With Praziquantel in the Treatment of Schistosomiasis Induced Hepatic Fibrosis.Schistosomiasis has been a fatal obstinate disease that threatens global human health, resulting in the granulomatous inflammation and liver fibrosis. <b>Objective:</b>The aim of this study was to evaluate the therapeutic effects and mechanisms of hydroxyasiaticoside combined with praziquantel in the treatment of schistosomiasis-induced liver fibrosis. <b>Methods:</b>Mice were randomly distributed into four experimental groups: normal control group, model group, praziquantel group, praziquantel + hydroxyasiaticoside group. Except for the normal control group, they were infected with <i>Schistosomia cercariae</i> through the abdominal skin to induce liver fibrosis. In the intervention group, mice were administered with the respective drugs by gavage after 8 weeks of infection. At the end of2020-01-01T00:00:00Z20202025-04-04T22:03:53.375Z2021-02-21T07:23:04ZS-EPMC78625693355312010.3389/fbioe.2020.613784