{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Terra L"],"pubmed_abstract":["<h4>Background</h4>BRCA1/2 mutation carriers are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO) at 35 to 45 years of age. RRSO substantially decreases ovarian cancer risk, but at the cost of immediate menopause. Knowledge about the potential adverse effects of premenopausal RRSO, such as increased risk of cardiovascular disease, osteoporosis, cognitive dysfunction, and reduced health-related quality of life (HRQoL), is limited.<h4>Objective</h4>The aim of this study is to assess the long-term health effects of premenopausal RRSO on cardiovascular disease, bone health, cognitive functioning, urological complaints, sexual functioning, and HRQoL in women with high familial risk of breast or ovarian cancer.<h4>Methods</h4>We will conduct a multicenter cross-sectional study w"],"journal":["JMIR research protocols"],"pagination":["e24414"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7864779"],"repository":["biostudies-literature"],"pubmed_title":["Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study)."],"pmcid":["PMC7864779"],"pubmed_authors":["Gaarenstroom KN","Leiner T","Schagen SB","van Engelen K","Maas AHEM","Hauptmann M","Bleiker EM","van Dorst EBL","van Leeuwen FE","Rookus MA","Roeters van Lennep JE","Mourits MJE","van Asperen CJ","Gomez-Garcia EB","Aaronson NK","van Beurden M","van der Kolk L","Heemskerk-Gerritsen BAM","van de Beek I","Hooning MJ","de Hullu JA","Zillikens MC","van Doorn HC","Ausems MGEM","Collee M","Wevers M","Berger LP","Slangen BFM","Terra L","Mom C"],"additional_accession":[]},"is_claimable":false,"name":"Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study).","description":"<h4>Background</h4>BRCA1/2 mutation carriers are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO) at 35 to 45 years of age. RRSO substantially decreases ovarian cancer risk, but at the cost of immediate menopause. Knowledge about the potential adverse effects of premenopausal RRSO, such as increased risk of cardiovascular disease, osteoporosis, cognitive dysfunction, and reduced health-related quality of life (HRQoL), is limited.<h4>Objective</h4>The aim of this study is to assess the long-term health effects of premenopausal RRSO on cardiovascular disease, bone health, cognitive functioning, urological complaints, sexual functioning, and HRQoL in women with high familial risk of breast or ovarian cancer.<h4>Methods</h4>We will conduct a multicenter cross-sectional study w","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-05-02T13:14:51.776Z","creation":"2021-02-21T09:23:06Z"},"accession":"S-EPMC7864779","cross_references":{"pubmed":["33480862"],"doi":["10.2196/24414"]}}