{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shrestha S"],"funding":["National Institute of Environmental Health Sciences","Intramural NIH HHS","NIEHS NIH HHS","National Cancer Institute","NCI NIH HHS"],"pagination":["332-335"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7866491"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["76(5)"],"pubmed_abstract":["<h4>Background</h4>Few studies have evaluated associations between pesticides and hyperthyroidism.<h4>Objective</h4>We evaluated associations between specific pesticides and incident hyperthyroidism in private pesticide applicators in the Agricultural Health Study.<h4>Methods</h4>We used Cox proportional hazards models to estimate HRs and 95% CIs for associations between pesticide use at enrolment and hyperthyroidism (n=271) in 35 150 applicators (mostly men), adjusting for potential confounders.<h4>Results</h4>Ever use of several pesticides (organophosphate insecticide malathion, fungicide maneb/mancozeb, herbicides dicamba, metolachlor, and atrazine in overall sample and chlorimuron ethyl among those ≤62 years) was associated with reduced hyperthyroidism risk, with HRs ranging from 0.50 (95% CI 0.30 to 0.83) for maneb/mancozeb to 0.77 (95% CI 0.59 to 1.00) for atrazine. Hyperthyroidism risk was lowest among those with higher intensity-weighted lifetime days of using carbofuran and chlorpyrifos (p<sub>trend</sub> ≤0.05).<h4>Conclusions</h4>Observed associations between pesticides and decreased risk of hyperthyroidism warrant further investigation."],"journal":["Occupational and environmental medicine"],"pubmed_title":["Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study."],"pmcid":["PMC7866491"],"funding_grant_id":["Z01 ES049030","Z01 CP010119"],"pubmed_authors":["Parks CG","Goldner WS","Koutros S","Beane Freeman LE","Ward MH","Hofmann JN","Umbach DM","Lerro CC","Sandler DP","Kamel F","Shrestha S"],"additional_accession":[]},"is_claimable":false,"name":"Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study.","description":"<h4>Background</h4>Few studies have evaluated associations between pesticides and hyperthyroidism.<h4>Objective</h4>We evaluated associations between specific pesticides and incident hyperthyroidism in private pesticide applicators in the Agricultural Health Study.<h4>Methods</h4>We used Cox proportional hazards models to estimate HRs and 95% CIs for associations between pesticide use at enrolment and hyperthyroidism (n=271) in 35 150 applicators (mostly men), adjusting for potential confounders.<h4>Results</h4>Ever use of several pesticides (organophosphate insecticide malathion, fungicide maneb/mancozeb, herbicides dicamba, metolachlor, and atrazine in overall sample and chlorimuron ethyl among those ≤62 years) was associated with reduced hyperthyroidism risk, with HRs ranging from 0.50 (95% CI 0.30 to 0.83) for maneb/mancozeb to 0.77 (95% CI 0.59 to 1.00) for atrazine. Hyperthyroidism risk was lowest among those with higher intensity-weighted lifetime days of using carbofuran and chlorpyrifos (p<sub>trend</sub> ≤0.05).<h4>Conclusions</h4>Observed associations between pesticides and decreased risk of hyperthyroidism warrant further investigation.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2024-02-15T09:13:45.164Z","creation":"2021-02-21T06:48:46Z"},"accession":"S-EPMC7866491","cross_references":{"pubmed":["30804163"],"doi":["10.1136/oemed-2018-105518"]}}