biostudies-literatureUnknown13(1)Zheng M<h4>Background</h4>There is currently no evidence regarding the role of plasma Sirtuin2 (SIRT2) level in acute myocardial infarction (AMI) yet. This study assessed the role of plasma SIRT2 in AMI, and investigated the association of plasma SIRT2 level with major adverse cardiovascular events (MACE) and heart failure after AMI.<h4>Methods</h4>This is a prospective observational study. A total of 129 AMI patients (mean age: 62.2±12.7 years old, male/female: 96/33) were included. Cox proportional hazards regression models were used to estimate the association of different SIRT2 levels with MACE and heart failure after AMI.<h4>Results</h4>According to the 75th percentile value of plasma SIRT2 level, we divided all the AMI patients into two groups: high-level group (plasma SIRT2 level ≥109.0 pgJournal of thoracic disease50-59https://www.ebi.ac.uk/biostudies/studies/S-EPMC7867809biostudies-literatureElevated plasma Sirtuin2 level predicts heart failure after acute myocardial infarction.PMC7867809Yang XZhao LZheng MChen MDu XSun HfalseElevated plasma Sirtuin2 level predicts heart failure after acute myocardial infarction.<h4>Background</h4>There is currently no evidence regarding the role of plasma Sirtuin2 (SIRT2) level in acute myocardial infarction (AMI) yet. This study assessed the role of plasma SIRT2 in AMI, and investigated the association of plasma SIRT2 level with major adverse cardiovascular events (MACE) and heart failure after AMI.<h4>Methods</h4>This is a prospective observational study. A total of 129 AMI patients (mean age: 62.2±12.7 years old, male/female: 96/33) were included. Cox proportional hazards regression models were used to estimate the association of different SIRT2 levels with MACE and heart failure after AMI.<h4>Results</h4>According to the 75th percentile value of plasma SIRT2 level, we divided all the AMI patients into two groups: high-level group (plasma SIRT2 level ≥109.0 pg2021-01-01T00:00:00Z2021 Jan2025-04-04T19:53:54.796Z2025-04-04T19:53:54.796ZS-EPMC78678093356918410.21037/jtd-20-2234