{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(2)"],"submitter":["Huang X"],"pubmed_abstract":["<h4>Background</h4>Cardiac arrest (CA), a common disease with a high mortality rate, is a leading cause of ischemia/reperfusion (I/R)-induced dysfunction of the intestinal barrier. Long non-coding RNAs (lncRNAs) play crucial roles in multiple pathological processes. However, the effect of the lncRNA maternally expressed 3 (MEG3) on intestinal I/R injury and the intestinal barrier has not been fully determined. Therefore, this study aimed to investigate the function of MEG3 in CA-induced intestinal barrier dysfunction.<h4>Methods</h4>The oxygen and glucose deprivation (OGD) model in the human colorectal adenocarcinoma Caco-2 cells and <i>in vivo</i> cardiac arrest-induced intestinal barrier dysfunction model in Sprague-Dawley (SD) rats were established. The effect and underlying mechanism o"],"journal":["Annals of translational medicine"],"pagination":["122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7867908"],"repository":["biostudies-literature"],"pubmed_title":["Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B signaling."],"pmcid":["PMC7867908"],"pubmed_authors":["Du P","Lu W","Huang X","Chen Y","Lin J","Zhang C","Pan M"],"additional_accession":[]},"is_claimable":false,"name":"Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B signaling.","description":"<h4>Background</h4>Cardiac arrest (CA), a common disease with a high mortality rate, is a leading cause of ischemia/reperfusion (I/R)-induced dysfunction of the intestinal barrier. Long non-coding RNAs (lncRNAs) play crucial roles in multiple pathological processes. However, the effect of the lncRNA maternally expressed 3 (MEG3) on intestinal I/R injury and the intestinal barrier has not been fully determined. Therefore, this study aimed to investigate the function of MEG3 in CA-induced intestinal barrier dysfunction.<h4>Methods</h4>The oxygen and glucose deprivation (OGD) model in the human colorectal adenocarcinoma Caco-2 cells and <i>in vivo</i> cardiac arrest-induced intestinal barrier dysfunction model in Sprague-Dawley (SD) rats were established. The effect and underlying mechanism o","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-04-04T19:40:55.355Z","creation":"2025-04-04T19:40:55.355Z"},"accession":"S-EPMC7867908","cross_references":{"pubmed":["33569424"],"doi":["10.21037/atm-20-6438"]}}