biostudies-literatureRossi INIDDK NIH HHSNational Institutes of Health539-542https://www.ebi.ac.uk/biostudies/studies/S-EPMC7870514biostudies-literatureUnknown169(3)<h4>Background</h4>Obesity and type 2 diabetes mellitus are associated with elevated levels of inflammatory markers. This chronic inflammation is known to contribute to increased risk of cardiovascular disease in these populations. Laparoscopic Roux-en-Y gastric bypass is associated with a high rate of diabetes remission. We hypothesize that laparoscopic Roux-en-Y gastric bypass decreases systemic inflammatory markers and cardiovascular disease risk factors in obese diabetics.<h4>Methods</h4>This was a single-institution prospective cohort study of 61 obese patients with type 2 diabetes mellitus. A total of 30 patients underwent laparoscopic Roux-en-Y gastric bypass surgery, and 31 patients underwent standard medical therapy with diabetes support and education. Collected data included preoSurgeryRoux-en-Y gastric bypass decreases serum inflammatory markers and cardiovascular risk factors in obese diabetics.PMC7870514K23 DK075907Torquati ARossi ISpagnoli APoirier JOmotosho PfalseRoux-en-Y gastric bypass decreases serum inflammatory markers and cardiovascular risk factors in obese diabetics.<h4>Background</h4>Obesity and type 2 diabetes mellitus are associated with elevated levels of inflammatory markers. This chronic inflammation is known to contribute to increased risk of cardiovascular disease in these populations. Laparoscopic Roux-en-Y gastric bypass is associated with a high rate of diabetes remission. We hypothesize that laparoscopic Roux-en-Y gastric bypass decreases systemic inflammatory markers and cardiovascular disease risk factors in obese diabetics.<h4>Methods</h4>This was a single-institution prospective cohort study of 61 obese patients with type 2 diabetes mellitus. A total of 30 patients underwent laparoscopic Roux-en-Y gastric bypass surgery, and 31 patients underwent standard medical therapy with diabetes support and education. Collected data included preo2021-01-01T00:00:00Z2021 Mar2025-04-18T12:11:44.078Z2025-04-06T21:48:22.072ZS-EPMC78705143316820910.1016/j.surg.2020.09.039