{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Esquivel-Elizondo S"],"funding":["Deutsche Forschungsgemeinschaft","Alexander von Humboldt-Stiftung"],"pagination":["594524"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7873966"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Bulk production of medium-chain carboxylates (MCCs) with 6-12 carbon atoms is of great interest to biotechnology. Open cultures (e.g., reactor microbiomes) have been utilized to generate MCCs in bioreactors. When in-line MCC extraction and prevention of product inhibition is required, the bioreactors have been operated at mildly acidic pH (5.0-5.5). However, model chain-elongating bacteria grow optimally at neutral pH values. Here, we isolated a chain-elongating bacterium (strain 7D4C2) that grows at mildly acidic pH. We studied its metabolism and compared its whole genome and the reverse β-oxidation (rBOX) genes to other bacteria. Strain 7D4C2 produces lactate, acetate, <i>n</i>-butyrate, <i>n</i>-caproate, biomass, and H<sub>2</sub>/CO<sub>2</sub> from hexoses. With only fructose as subs"],"journal":["Frontiers in microbiology"],"pubmed_title":["The Isolate <i>Caproiciproducens</i> sp. 7D4C2 Produces <i>n</i>-Caproate at Mildly Acidic Conditions From Hexoses: Genome and rBOX Comparison With Related Strains and Chain-Elongating Bacteria."],"pmcid":["PMC7873966"],"funding_grant_id":["EXC 2124 – 390838134","HU 566/12-1"],"pubmed_authors":["Jeon BS","Bessarab I","Esquivel-Elizondo S","Huson DH","Bagcı C","Angenent LT","Williams RBH","Temovska M"],"additional_accession":[]},"is_claimable":false,"name":"The Isolate <i>Caproiciproducens</i> sp. 7D4C2 Produces <i>n</i>-Caproate at Mildly Acidic Conditions From Hexoses: Genome and rBOX Comparison With Related Strains and Chain-Elongating Bacteria.","description":"Bulk production of medium-chain carboxylates (MCCs) with 6-12 carbon atoms is of great interest to biotechnology. Open cultures (e.g., reactor microbiomes) have been utilized to generate MCCs in bioreactors. When in-line MCC extraction and prevention of product inhibition is required, the bioreactors have been operated at mildly acidic pH (5.0-5.5). However, model chain-elongating bacteria grow optimally at neutral pH values. Here, we isolated a chain-elongating bacterium (strain 7D4C2) that grows at mildly acidic pH. We studied its metabolism and compared its whole genome and the reverse β-oxidation (rBOX) genes to other bacteria. Strain 7D4C2 produces lactate, acetate, <i>n</i>-butyrate, <i>n</i>-caproate, biomass, and H<sub>2</sub>/CO<sub>2</sub> from hexoses. With only fructose as subs","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-05-02T13:18:39.749Z","creation":"2021-02-21T10:44:09Z"},"accession":"S-EPMC7873966","cross_references":{"pubmed":["33584563"],"doi":["10.3389/fmicb.2020.594524"]}}