{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Tay IYY"],"funding":["Yale-NUS College"],"pubmed_abstract":["The evolution of Crassulacean acid metabolism (CAM) is thought to be along a C<sub>3</sub>-CAM continuum including multiple variations of CAM such as CAM cycling and CAM idling. Here, we applied large-scale constraint-based modeling to investigate the metabolism and energetics of plants operating in C<sub>3</sub>, CAM, CAM cycling, and CAM idling. Our modeling results suggested that CAM cycling and CAM idling could be potential evolutionary intermediates in CAM evolution by establishing a starch/sugar-malate cycle. Our model analysis showed that by varying CO<sub>2</sub> exchange during the light period, as a proxy of stomatal conductance, there exists a C<sub>3</sub>-CAM continuum with gradual metabolic changes, supporting the notion that evolution of CAM from C<sub>3</sub> could occur so"],"journal":["Frontiers in plant science"],"pagination":["573197"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7874232"],"repository":["biostudies-literature"],"pubmed_title":["Metabolic Modeling of the C<sub>3</sub>-CAM Continuum Revealed the Establishment of a Starch/Sugar-Malate Cycle in CAM Evolution."],"pmcid":["PMC7874232"],"pubmed_authors":["Cheung CYM","Odang KB","Tay IYY"],"additional_accession":[]},"is_claimable":false,"name":"Metabolic Modeling of the C<sub>3</sub>-CAM Continuum Revealed the Establishment of a Starch/Sugar-Malate Cycle in CAM Evolution.","description":"The evolution of Crassulacean acid metabolism (CAM) is thought to be along a C<sub>3</sub>-CAM continuum including multiple variations of CAM such as CAM cycling and CAM idling. Here, we applied large-scale constraint-based modeling to investigate the metabolism and energetics of plants operating in C<sub>3</sub>, CAM, CAM cycling, and CAM idling. Our modeling results suggested that CAM cycling and CAM idling could be potential evolutionary intermediates in CAM evolution by establishing a starch/sugar-malate cycle. Our model analysis showed that by varying CO<sub>2</sub> exchange during the light period, as a proxy of stomatal conductance, there exists a C<sub>3</sub>-CAM continuum with gradual metabolic changes, supporting the notion that evolution of CAM from C<sub>3</sub> could occur so","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-04T11:53:53.385Z","creation":"2021-02-21T10:03:23Z"},"accession":"S-EPMC7874232","cross_references":{"pubmed":["33584741"],"doi":["10.3389/fpls.2020.573197"]}}