biostudies-literatureGarg RKAmerican Heart AssociationNIBIB NIH HHSNCATS NIH HHSRush University Department of Neurological SciencesWake Forest CTSI NCATSNational Institute of Biomedical Imaging and Bioengineering552-564https://www.ebi.ac.uk/biostudies/studies/S-EPMC7875455biostudies-literatureUnknown33(2)<h4>Background/objective</h4>Diffusion weighted imaging (DWI) lesions have been well described in patients with acute spontaneous intracerebral hemorrhage (sICH). However, there are limited data on the influence of these lesions on sICH functional outcomes. We conducted a prospective observational cohort study with blinded imaging and outcomes assessment to determine the influence of DWI lesions on long-term outcomes in patients with acute sICH. We hypothesized that DWI lesions are associated with worse modified Rankin Scale (mRS) at 3 months after hospital discharge.<h4>Methods</h4>Consecutive sICH patients meeting study criteria were consented for an magnetic resonance imaging (MRI) scan of the brain and evaluated for remote DWI lesions by neuroradiologists blinded to the patients' hospiNeurocritical careThe Influence of Diffusion Weighted Imaging Lesions on Outcomes in Patients with Acute Spontaneous Intracerebral Hemorrhage.PMC7875455R01 EB024559UL1TR001420K25 EB012236UL1 TR00142011CRP7520073R01EB024559Bhabad SOuyang BDawe RJBleck TPKhan JConners JPrabhakaran SSimpson SLKocak MJhaveri MGarg RKJohn SfalseThe Influence of Diffusion Weighted Imaging Lesions on Outcomes in Patients with Acute Spontaneous Intracerebral Hemorrhage.<h4>Background/objective</h4>Diffusion weighted imaging (DWI) lesions have been well described in patients with acute spontaneous intracerebral hemorrhage (sICH). However, there are limited data on the influence of these lesions on sICH functional outcomes. We conducted a prospective observational cohort study with blinded imaging and outcomes assessment to determine the influence of DWI lesions on long-term outcomes in patients with acute sICH. We hypothesized that DWI lesions are associated with worse modified Rankin Scale (mRS) at 3 months after hospital discharge.<h4>Methods</h4>Consecutive sICH patients meeting study criteria were consented for an magnetic resonance imaging (MRI) scan of the brain and evaluated for remote DWI lesions by neuroradiologists blinded to the patients' hospi2020-01-01T00:00:00Z2020 Oct2025-04-22T03:01:06.747Z2025-04-05T20:34:32.579ZS-EPMC78754553207245710.1007/s12028-020-00933-3