{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aguas R"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","RCUK | Medical Research Council","Li Ka Shing Foundation","Oxford University | Nuffield College, University of Oxford"],"pagination":["915"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7875992"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Dexamethasone can reduce mortality in hospitalised COVID-19 patients needing oxygen and ventilation by 18% and 36%, respectively. Here, we estimate the potential number of lives saved and life years gained if this treatment were to be rolled out in the UK and globally, as well as the cost-effectiveness of implementing this intervention. Assuming SARS-CoV-2 exposure levels of 5% to 15%, we estimate that, for the UK, approximately 12,000 (4,250 - 27,000) lives could be saved between July and December 2020. Assuming that dexamethasone has a similar effect size in settings where access to oxygen therapies is limited, this would translate into approximately 650,000 (240,000 - 1,400,000) lives saved globally over the same time period. If dexamethasone acts differently in these settings, the impact could be less than half of this value. To estimate the full potential of dexamethasone in the global fight against COVID-19, it is essential to perform clinical research in settings with limited access to oxygen and/or ventilators, for example in low- and middle-income countries."],"journal":["Nature communications"],"pubmed_title":["Potential health and economic impacts of dexamethasone treatment for patients with COVID-19."],"pmcid":["PMC7875992"],"funding_grant_id":["COVID-19 Research Response Fund","MC_PC_19056","MC_PC_20029"],"pubmed_authors":["Nji AM","Hancock P","Jamshidi B","Freitas LT","Azzeri A","Aguas R","Landray M","Eybpoosh S","Sharifi H","Ximenes A","Lubis IND","Zhumalieva C","Dahlui M","Moldokmatova A","Celhay O","Arifi F","Letchford N","de Colombi NF","Saralamba S","Harsono H","Tbalasubramaniam BL","Chen S","Hussain M","Abdyldaev T","Klein MG","Medina JRC","Getachew B","Hupert N","Nasir N","Ariana P","Salim AH","Sarin KC","Wattanasri P","Tun STT","Alona I","Yunanda Y","Kutmanova A","Obando F","Mahdi A","Monteiro AB","Adele S","Mzumara GW","Martins J","Zaman RU","White L","CoMo Consortium","Pokharel S","Fariba MH","Kyaw SS","Shretta R","Chanthavilay P","Obiesie S","Aung YN","Nwosu AP","Luangasanatip N","Estebesova A","Bekrizadeh H","Omoleke SA","Advani N","Saeedzai SA","Jabin N","Marzouk M","Adib K","Lata D","Kraenkel RA","Niha MAV","Ibragimov S","Sahak MN","Alves LRF","Herrera-Diestra JL","Dooronbekova A","Horby P","Hairi NN","Mabombo V","Mukambetov A","Pan-Ngum W","Kubatova A","Shimul SN","Franco C","Coutinho RM","Aderoba AK","Shabaruddin F","Mercado CEG","Bakare EA","Naidoo R","Namedre M","Monteiro M","Suarez-Idueta L"],"additional_accession":[]},"is_claimable":false,"name":"Potential health and economic impacts of dexamethasone treatment for patients with COVID-19.","description":"Dexamethasone can reduce mortality in hospitalised COVID-19 patients needing oxygen and ventilation by 18% and 36%, respectively. Here, we estimate the potential number of lives saved and life years gained if this treatment were to be rolled out in the UK and globally, as well as the cost-effectiveness of implementing this intervention. Assuming SARS-CoV-2 exposure levels of 5% to 15%, we estimate that, for the UK, approximately 12,000 (4,250 - 27,000) lives could be saved between July and December 2020. Assuming that dexamethasone has a similar effect size in settings where access to oxygen therapies is limited, this would translate into approximately 650,000 (240,000 - 1,400,000) lives saved globally over the same time period. If dexamethasone acts differently in these settings, the impact could be less than half of this value. To estimate the full potential of dexamethasone in the global fight against COVID-19, it is essential to perform clinical research in settings with limited access to oxygen and/or ventilators, for example in low- and middle-income countries.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2024-02-14T19:52:46.716Z","creation":"2021-02-27T08:16:05Z"},"accession":"S-EPMC7875992","cross_references":{"pubmed":["33568665"],"doi":["10.1038/s41467-021-21134-2"]}}