biostudies-literatureUnknown78(5)Mucci A<h4>Importance</h4>The goal of schizophrenia treatment has shifted from symptom reduction and relapse prevention to functional recovery; however, recovery rates remain low. Prospective identification of variables associated with real-life functioning domains is essential for personalized and integrated treatment programs.<h4>Objective</h4>To assess whether baseline illness-related variables, personal resources, and context-related factors are associated with work skills, interpersonal relationships, and everyday life skills at 4-year follow-up.<h4>Design, setting, and participants</h4>This multicenter prospective cohort study was conducted across 24 Italian university psychiatric clinics or mental health departments in which 921 patients enrolled in a cross-sectional study were contacted aJAMA psychiatry550-559https://www.ebi.ac.uk/biostudies/studies/S-EPMC7876615biostudies-literatureFactors Associated With Real-Life Functioning in Persons With Schizophrenia in a 4-Year Follow-up Study of the Italian Network for Research on Psychoses.PMC7876615Mammarella SMartinotti GAmore MBrasso CPapalino MPiegari GCorrivetti GBlasi GMaj MMarchesi CMonteleone PAngelini EGerardi NRossi RSurace TSalza ACascino GGiusti LCalia VComparelli AFusar Poli LCollantoni EMeneguzzo PMontemagni CRomano RSiracusano APettorruso MRossi AVita ACalcagno PBinda VCarmassi CCarpita BGiuliani LMucci AOldani LItalian Network for Research on PsychosesPalumbo DCattedra SOssola PTenconi EValsecchi PSocci VPompili MLostia di Santa Sofia SMontemitro CGerra MLRoncone RBelvederi Murri MDi Lorenzo GDel Buono GNiolu CDeste GGalderisi SBertolino ABucci PBarlati SBrugnoli RAguglia ELai AAiello Cde Bartolomeis AGambaro EFavaro AAltamura MCuomo ABellomo AGoracci AZeppegno PBrando FBiondi MBolognesi SBuzzanca ARiccardi CElia ADel Favero ECremone IMTonna MFrascarelli MCarpiniello BCorigliano VTalevi DPinna FFagiolini ARibolsi MDell'Osso LCoccia CFraticelli SGiordano GMGramaglia CGibertoni DPacitti FSignorelli MSRocca PfalseFactors Associated With Real-Life Functioning in Persons With Schizophrenia in a 4-Year Follow-up Study of the Italian Network for Research on Psychoses.<h4>Importance</h4>The goal of schizophrenia treatment has shifted from symptom reduction and relapse prevention to functional recovery; however, recovery rates remain low. Prospective identification of variables associated with real-life functioning domains is essential for personalized and integrated treatment programs.<h4>Objective</h4>To assess whether baseline illness-related variables, personal resources, and context-related factors are associated with work skills, interpersonal relationships, and everyday life skills at 4-year follow-up.<h4>Design, setting, and participants</h4>This multicenter prospective cohort study was conducted across 24 Italian university psychiatric clinics or mental health departments in which 921 patients enrolled in a cross-sectional study were contacted a2021-01-01T00:00:00Z2021 May2025-04-20T03:43:51.278Z2025-04-20T03:43:51.278ZS-EPMC78766153356607110.1001/jamapsychiatry.2020.4614