biostudies-literatureDennis CLCanadian Institutes of Health ResearchCIHRe046311https://www.ebi.ac.uk/biostudies/studies/S-EPMC7878148biostudies-literatureUnknown11(2)<h4>Introduction</h4>The 'Developmental Origins of Health and Disease' hypothesis suggests that a healthy trajectory of growth and development in pregnancy and early childhood is necessary for optimal health, development and lifetime well-being. The purpose of this paper is to present the protocol for a randomised controlled trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada). The primary objective of HeLTI Canada is to determine whether a 4-phase 'preconception to early childhood' lifecourse intervention can reduce the rate of child overweight and obesity. Secondary objectives include improvBMJ openProtocol for a randomised trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada).PMC7878148HLC-154502Misita DMillar DRay JLetourneau NGuttmann AParekh RSConstantin EMatthews SGSmith GNMaguire JLDick JABerard ATelnner DPaterson AMurphy KSemenic SThorpe KVigod SJanus MBarrett JScherer SO'Connor DLNuyt AMWalker MShah PSTremblay MSSzatmari PKimmins SLi PBerger HLye SBrown HKJoseph KSBell RMarini FRoumeliotis PAtkinson SFeller APuts MBirken CJuni PSellen DDennis CLStremler RDa Costa DfalseProtocol for a randomised trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada).<h4>Introduction</h4>The 'Developmental Origins of Health and Disease' hypothesis suggests that a healthy trajectory of growth and development in pregnancy and early childhood is necessary for optimal health, development and lifetime well-being. The purpose of this paper is to present the protocol for a randomised controlled trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada). The primary objective of HeLTI Canada is to determine whether a 4-phase 'preconception to early childhood' lifecourse intervention can reduce the rate of child overweight and obesity. Secondary objectives include improv2021-01-01T00:00:00Z2021 Feb2025-05-29T20:50:52.517Z2025-05-29T20:50:52.517ZS-EPMC78781483356838010.1136/bmjopen-2020-046311