{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Michoud F"],"funding":["Swiss National Science Foundation","Fondation Bertarelli","Sir Henry Dale fellowship jointly funded by the Wellcome Trust and the Royal Society","NINDS NIH HHS","European Union&apos;s Horizon 2020 reserach and innovation program under the Marie Sklodowska-Curie grant agreement","Wellcome Trust"],"pagination":["179-185"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7878280"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(2)"],"pubmed_abstract":["Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation<sup>1,2</sup>, but whether nociceptors also interact with the immune system remains poorly understood. Here we report a neurotechnology for selective epineural optogenetic neuromodulation of nociceptors and demonstrate that nociceptor activation drives both protective pain behavior and inflammation. The wireless optoelectronic system consists of sub-millimeter-scale light-emitting diodes embedded in a soft, circumneural sciatic nerve implant, powered and driven by a miniaturized head-mounted control unit. Photostimulation of axons in freely moving mice that express channelrhodopsin only in nociceptors resulted in behaviors cha"],"journal":["Nature biotechnology"],"pubmed_title":["Epineural optogenetic activation of nociceptors initiates and amplifies inflammation."],"pmcid":["PMC7878280"],"funding_grant_id":["BSCGI0_1578000","109372/Z/15/Z","R35 NS105076"],"pubmed_authors":["Browne LE","Furfaro I","Doyle B","Lacour SP","Moon R","Michoud F","Brun N","Galan K","Huang Q","Akouissi O","Woolf CJ","Jain A","Tetreault M","Zhang Z","Seehus C","Schonle P","Talbot S","Taub D","Meier P"],"additional_accession":[]},"is_claimable":false,"name":"Epineural optogenetic activation of nociceptors initiates and amplifies inflammation.","description":"Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation<sup>1,2</sup>, but whether nociceptors also interact with the immune system remains poorly understood. Here we report a neurotechnology for selective epineural optogenetic neuromodulation of nociceptors and demonstrate that nociceptor activation drives both protective pain behavior and inflammation. The wireless optoelectronic system consists of sub-millimeter-scale light-emitting diodes embedded in a soft, circumneural sciatic nerve implant, powered and driven by a miniaturized head-mounted control unit. Photostimulation of axons in freely moving mice that express channelrhodopsin only in nociceptors resulted in behaviors cha","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-03T23:45:42.644Z","creation":"2025-04-03T23:45:42.644Z"},"accession":"S-EPMC7878280","cross_references":{"pubmed":["32958958"],"doi":["10.1038/s41587-020-0673-2"]}}