{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garvin AM"],"funding":["BLRD VA","NHLBI NIH HHS"],"pagination":["904-918"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7878436"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(3)"],"pubmed_abstract":["Transient ACE (angiotensin-converting enzyme) inhibition in spontaneously hypertensive rats is known to protect against future injury-induced cardiac inflammation, fibrosis, and dysfunction; however, the mechanisms of protection have not been delineated. Here, we used single-cell RNA sequencing to test the hypothesis that transient ACE inhibitor treatment would induce a persistent shift in cardiac fibroblast subpopulations. Adult male spontaneously hypertensive rats (11 weeks old, hypertensive with cardiac hypertrophy) were treated for 2 weeks with an ACE inhibitor, enalapril (30 mg/kg per day, PO), or water (untreated spontaneously hypertensive rats) followed by a 2-week washout period (n=7/group). Cardiac fibroblasts were isolated from the left ventricle and subjected to single-cell RNA "],"journal":["Hypertension (Dallas, Tex. : 1979)"],"pubmed_title":["Transient ACE (Angiotensin-Converting Enzyme) Inhibition Suppresses Future Fibrogenic Capacity and Heterogeneity of Cardiac Fibroblast Subpopulations."],"pmcid":["PMC7878436"],"funding_grant_id":["R56 HL141165","I01 BX000505","R01 HL137319","R01 HL129823"],"pubmed_authors":["Garvin AM","Hale TM","De Both MD","Lindsey ML","Talboom JS","Huentelman MJ"],"additional_accession":[]},"is_claimable":false,"name":"Transient ACE (Angiotensin-Converting Enzyme) Inhibition Suppresses Future Fibrogenic Capacity and Heterogeneity of Cardiac Fibroblast Subpopulations.","description":"Transient ACE (angiotensin-converting enzyme) inhibition in spontaneously hypertensive rats is known to protect against future injury-induced cardiac inflammation, fibrosis, and dysfunction; however, the mechanisms of protection have not been delineated. Here, we used single-cell RNA sequencing to test the hypothesis that transient ACE inhibitor treatment would induce a persistent shift in cardiac fibroblast subpopulations. Adult male spontaneously hypertensive rats (11 weeks old, hypertensive with cardiac hypertrophy) were treated for 2 weeks with an ACE inhibitor, enalapril (30 mg/kg per day, PO), or water (untreated spontaneously hypertensive rats) followed by a 2-week washout period (n=7/group). Cardiac fibroblasts were isolated from the left ventricle and subjected to single-cell RNA ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-05-02T11:23:18.791Z","creation":"2025-02-19T03:26:26.997Z"},"accession":"S-EPMC7878436","cross_references":{"pubmed":["33486989"],"doi":["10.1161/HYPERTENSIONAHA.120.16352","10.1161/hypertensionaha.120.16352"]}}