{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(6)"],"submitter":["Zylbersztejn A"],"funding":["National Institute for Health Research (NIHR)","Wellcome Trust"],"pubmed_abstract":["BackgroundBronchiolitis caused by respiratory syncytial virus (RSV) is a major cause of mortality and morbidity in infants.AimTo describe RSV epidemiology in children in the community in a high-income setting.MethodsWe used stored blood samples from the United Kingdom Born in Bradford cohort study that had been collected at birth, age 1 and 2 years old, tested for IgG RSV postfusion F antibody and linked to questionnaires and primary and hospital care records. We used finite mixture models to classify children as RSV infected/not infected according to their antibody concentrations at age 1 and 2 years. We assessed risk factors for primary RSV infection at each age using Poisson regression models.ResultsThe study cohort included 700 children with cord blood samples; 490 had additional blood"],"journal":["Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7879500"],"repository":["biostudies-literature"],"pubmed_title":["Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013."],"pmcid":["PMC7879500"],"funding_grant_id":["207673/Z/17/Z","NF-SI-0510-10075"],"pubmed_authors":["Smyth R","Zylbersztejn A","Goldstein H","Pembrey L","Schepp R","van der Klis F","Wright J","Hardelid P","Berbers G","Sande C","Mason D"],"additional_accession":[]},"is_claimable":false,"name":"Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013.","description":"BackgroundBronchiolitis caused by respiratory syncytial virus (RSV) is a major cause of mortality and morbidity in infants.AimTo describe RSV epidemiology in children in the community in a high-income setting.MethodsWe used stored blood samples from the United Kingdom Born in Bradford cohort study that had been collected at birth, age 1 and 2 years old, tested for IgG RSV postfusion F antibody and linked to questionnaires and primary and hospital care records. We used finite mixture models to classify children as RSV infected/not infected according to their antibody concentrations at age 1 and 2 years. We assessed risk factors for primary RSV infection at each age using Poisson regression models.ResultsThe study cohort included 700 children with cord blood samples; 490 had additional blood","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-04T19:15:12.914Z","creation":"2021-02-26T08:12:44Z"},"accession":"S-EPMC7879500","cross_references":{"pubmed":["33573711"],"doi":["10.2807/1560-7917.ES.2021.26.6.2000023"]}}