{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Horowitz AM"],"funding":["NIA NIH HHS","National Institute on Aging"],"pagination":["167-173"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7879650"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["369(6500)"],"pubmed_abstract":["Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. Plasma concentrations of glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate cleavage."],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain."],"pmcid":["PMC7879650"],"funding_grant_id":["K23 AG058752","R01 AG067740","AG058752","AG023501","R01 AG053382","F32 AG064823","P50 AG023501","AG053382","P30 AG062422","AG055797","RF1 AG032289","R01 AG032289"],"pubmed_authors":["Bieri G","Casaletto KB","Sanchez-Diaz CI","Horowitz AM","Fan X","Smith LK","Williams KE","Schroer AB","Gontier G","Villeda SA","Kramer JH"],"additional_accession":[]},"is_claimable":false,"name":"Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.","description":"Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. Plasma concentrations of glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate cleavage.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-18T15:59:55.406Z","creation":"2025-04-07T02:55:19.22Z"},"accession":"S-EPMC7879650","cross_references":{"pubmed":["32646997"],"doi":["10.1126/science.aaw2622"]}}