biostudies-literatureUnknown268(2)Picillo MBoehringer Ingelheim<h4>Objectives</h4>To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson's disease at early stages.<h4>Methods</h4>A total of 385 Parkinson's disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women).<h4>Results</h4>As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only.<Journal of neurology448-454https://www.ebi.ac.uk/biostudies/studies/S-EPMC7880965biostudies-literatureThe PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease.PMC7880965Simone PSoliveri PGiglia RMZappulla STroianiello BAbbruzzese GFloris GCapecci MPontieri FEAlbanese ACiccarelli GAlfano RMarano RBarone PGriffini SPilleri EGallerini SFabbrini GMassimo PBartolomei LPRIAMO study groupPezzoli GBottacchi EDeriu MScaravilli TMorgante LLanfranchi SPepe FDe Falco FABenincasa DGaglio RMMucchiut MBentivoglio AErro RAntonini AStocchi FTiple DMorgante FCocco GAMoschella VRomeno MLogi CBaratti MLopiano LGurgone GPisani AMaiello LManfredi MAgnetti VModica CPicillo MZanini SMeco GQuatrale RNicoletti AMartinelli PSantangelo GFerigo LPerini MColosimo CAvarello TPMeoni SCannas ASciortino GGrasso LUlivelli MBraga MCaravona NConsoli DIemolo FBiguzzi SIellamo MPennisi FSorbello VAbrignani MAmidei SCiacci GRandisi MGDel Dotto PDe Gaspari DSavica RPesare MFogli DCuomo TCossu GScala RMuoio RKiferle LMilan EPetretta VCapus LRamat SGuidubaldi ALuciano RDi Giovanni MNordera GVolpe GScaglione CScaglioni AToni VTrianni GPalladino RMedici DNastasi VPetrone ACeravolo GGiaccaglini EAlesi CDi Brigida GMarconi RCeravolo RAlbani GfalseThe PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease.<h4>Objectives</h4>To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson's disease at early stages.<h4>Methods</h4>A total of 385 Parkinson's disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women).<h4>Results</h4>As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only.<2021-01-01T00:00:00Z2021 Feb2025-04-21T13:58:30.865Z2021-02-21T11:42:49ZS-EPMC78809653280915110.1007/s00415-020-10156-3