{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lopes R"],"funding":["Centro de Estudos do Ambiente e do Mar","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico","Fundação de Amparo à Pesquisa do Estado de São Paulo","Bill and Melinda Gates Foundation"],"pagination":["e01125-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7883542"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(1)"],"pubmed_abstract":["The global spread of antibiotic-resistant bacteria and their resistance genes is a critical issue that is no longer restricted to hospital settings, but also represents a growing problem involving environmental and food safety. In this study, we have performed a microbiological and genomic investigation of critical priority pathogens resistant to broad-spectrum cephalosporins and showing endophytic lifestyles in fresh vegetables sold in a country with high endemicity of extended-spectrum β-lactamases (ESBLs). We report the isolation of international high-risk clones of CTX-M-15-producing Escherichia coli, belonging to clonal complexes CC38 and CC648, and Klebsiella pneumoniae of complex CC307 from macerated tissue of surface-sterilized leaves of spinach, cabbage, arugula, and lettuce. Rega"],"journal":["mSystems"],"pubmed_title":["Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?"],"pmcid":["PMC7883542"],"funding_grant_id":["1541491/2015-8","15/21325-0","312249/2017-9","UIDB/50017/2020","443819/2018-1","433128/2018-6","OPP1193112","UIDP/50017/2020","2016/08593-9"],"pubmed_authors":["Lopes R","Cerdeira L","Dantas K","Fuentes-Castillo D","Lincopan N","Henriques I","Rodrigues L","Fontana H"],"additional_accession":[]},"is_claimable":false,"name":"Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?","description":"The global spread of antibiotic-resistant bacteria and their resistance genes is a critical issue that is no longer restricted to hospital settings, but also represents a growing problem involving environmental and food safety. In this study, we have performed a microbiological and genomic investigation of critical priority pathogens resistant to broad-spectrum cephalosporins and showing endophytic lifestyles in fresh vegetables sold in a country with high endemicity of extended-spectrum β-lactamases (ESBLs). We report the isolation of international high-risk clones of CTX-M-15-producing Escherichia coli, belonging to clonal complexes CC38 and CC648, and Klebsiella pneumoniae of complex CC307 from macerated tissue of surface-sterilized leaves of spinach, cabbage, arugula, and lettuce. Rega","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-05-29T21:45:18.428Z","creation":"2022-02-11T12:37:59.485Z"},"accession":"S-EPMC7883542","cross_references":{"pubmed":["33563779"],"doi":["10.1128/mSystems.01125-20"]}}