biostudies-literatureLei LMedical Research CouncilNational Natural Science Foundation of ChinaUK MRC DETER-XDR-China-HUBBiotechnology and Biological Sciences Research Council242-251https://www.ebi.ac.uk/biostudies/studies/S-EPMC7889244biostudies-literatureUnknown10(1)Mobile colistin resistance gene <i>mcr-1</i> and extended-spectrum <i>β</i>-lactamase gene <i>bla</i> <sub>CTX-M</sub> are highly prevalent in human - and pet-derived bacteria. Isolation of identical strains of <i>mcr-1</i>-positive <i>Escherichia coli</i> (MCRPEC) or <i>bla</i> <sub>CTX-M</sub>-positive <i>E. coli</i> (CTX-MPEC) from pets and humans highlighted the potential for co-colonization of antibiotic-resistant bacteria which can be a risk for dissemination of resistance genes. In this study, the prevalence of <i>mcr-1</i> and <i>bla</i> <sub>CTX-M</sub> carriage from rectal swabs in 299 families (dogs and their owners) were 2.7 and 5.3%, respectively. We identified a significant association of <i>mcr-1</i> carriage between dogs and their owners. Whilst antibiotic use in the previoEmerging microbes & infectionsPrevalence and risk analysis of mobile colistin resistance and extended-spectrum <i>β</i>-lactamase genes carriage in pet dogs and their owners: a population based cross-sectional study.PMC788924481861138051BB/R012776/1MR/S013768/281991535MR/S013768/1Lei LZou ZShi LCai CShen JHe JWalsh TRLiu QZhong YWang YYang DJia JfalsePrevalence and risk analysis of mobile colistin resistance and extended-spectrum <i>β</i>-lactamase genes carriage in pet dogs and their owners: a population based cross-sectional study.Mobile colistin resistance gene <i>mcr-1</i> and extended-spectrum <i>β</i>-lactamase gene <i>bla</i> <sub>CTX-M</sub> are highly prevalent in human - and pet-derived bacteria. Isolation of identical strains of <i>mcr-1</i>-positive <i>Escherichia coli</i> (MCRPEC) or <i>bla</i> <sub>CTX-M</sub>-positive <i>E. coli</i> (CTX-MPEC) from pets and humans highlighted the potential for co-colonization of antibiotic-resistant bacteria which can be a risk for dissemination of resistance genes. In this study, the prevalence of <i>mcr-1</i> and <i>bla</i> <sub>CTX-M</sub> carriage from rectal swabs in 299 families (dogs and their owners) were 2.7 and 5.3%, respectively. We identified a significant association of <i>mcr-1</i> carriage between dogs and their owners. Whilst antibiotic use in the previo2021-01-01T00:00:00Z2021 Dec2026-04-18T01:18:38.721Z2021-02-26T08:12:57ZS-EPMC78892443350294610.1080/22221751.2021.1882884