{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["34(1)"],"submitter":["Ramot Y"],"pubmed_abstract":["Fracture-related infections remain a leading cause of morbidity and mortality. We aimed to establish a simple contaminated radial osteotomy model to assess the efficacy of a biodegradable polymer poly(sebacic-co-ricinoleic acid) [p(SA-RA)] containing 20% w/w gentamicin. A unilateral transverse osteotomy was induced in Sprague-Dawley (SD) rats, followed by application of <i>Staphylococcus aureus</i> suspension over the fracture. After successfully establishing the contaminated open fracture model, we treated the rats either systemically (intraperitoneal cefuroxime), locally with p(SA-RA) containing gentamicin, or both. Control groups included non-contaminated group and contaminated groups that were either untreated or treated with the polymer alone. After 4 weeks, the bones were subjected t"],"journal":["Journal of toxicologic pathology"],"pagination":["11-22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7890171"],"repository":["biostudies-literature"],"pubmed_title":["Treatment of contaminated radial fracture in Sprague-Dawley rats by application of a degradable polymer releasing gentamicin."],"pmcid":["PMC7890171"],"pubmed_authors":["Amouyal N","Ramot Y","Domb AJ","Hagigit T","Nyska A","Lavie Y","Klaiman G","Steiner M"],"additional_accession":[]},"is_claimable":false,"name":"Treatment of contaminated radial fracture in Sprague-Dawley rats by application of a degradable polymer releasing gentamicin.","description":"Fracture-related infections remain a leading cause of morbidity and mortality. We aimed to establish a simple contaminated radial osteotomy model to assess the efficacy of a biodegradable polymer poly(sebacic-co-ricinoleic acid) [p(SA-RA)] containing 20% w/w gentamicin. A unilateral transverse osteotomy was induced in Sprague-Dawley (SD) rats, followed by application of <i>Staphylococcus aureus</i> suspension over the fracture. After successfully establishing the contaminated open fracture model, we treated the rats either systemically (intraperitoneal cefuroxime), locally with p(SA-RA) containing gentamicin, or both. Control groups included non-contaminated group and contaminated groups that were either untreated or treated with the polymer alone. After 4 weeks, the bones were subjected t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-04-04T21:15:58.319Z","creation":"2021-02-28T08:20:29Z"},"accession":"S-EPMC7890171","cross_references":{"pubmed":["33627941"],"doi":["10.1293/tox.2020-0041"]}}