biostudies-literatureUnknown34(1)Ramot YFracture-related infections remain a leading cause of morbidity and mortality. We aimed to establish a simple contaminated radial osteotomy model to assess the efficacy of a biodegradable polymer poly(sebacic-co-ricinoleic acid) [p(SA-RA)] containing 20% w/w gentamicin. A unilateral transverse osteotomy was induced in Sprague-Dawley (SD) rats, followed by application of <i>Staphylococcus aureus</i> suspension over the fracture. After successfully establishing the contaminated open fracture model, we treated the rats either systemically (intraperitoneal cefuroxime), locally with p(SA-RA) containing gentamicin, or both. Control groups included non-contaminated group and contaminated groups that were either untreated or treated with the polymer alone. After 4 weeks, the bones were subjected tJournal of toxicologic pathology11-22https://www.ebi.ac.uk/biostudies/studies/S-EPMC7890171biostudies-literatureTreatment of contaminated radial fracture in Sprague-Dawley rats by application of a degradable polymer releasing gentamicin.PMC7890171Amouyal NRamot YDomb AJHagigit TNyska ALavie YKlaiman GSteiner MfalseTreatment of contaminated radial fracture in Sprague-Dawley rats by application of a degradable polymer releasing gentamicin.Fracture-related infections remain a leading cause of morbidity and mortality. We aimed to establish a simple contaminated radial osteotomy model to assess the efficacy of a biodegradable polymer poly(sebacic-co-ricinoleic acid) [p(SA-RA)] containing 20% w/w gentamicin. A unilateral transverse osteotomy was induced in Sprague-Dawley (SD) rats, followed by application of <i>Staphylococcus aureus</i> suspension over the fracture. After successfully establishing the contaminated open fracture model, we treated the rats either systemically (intraperitoneal cefuroxime), locally with p(SA-RA) containing gentamicin, or both. Control groups included non-contaminated group and contaminated groups that were either untreated or treated with the polymer alone. After 4 weeks, the bones were subjected t2021-01-01T00:00:00Z2021 Jan2025-04-04T21:15:58.319Z2021-02-28T08:20:29ZS-EPMC78901713362794110.1293/tox.2020-0041