{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yao W"],"funding":["Department of Science and Technology of Henan Province","Applied Research in the Diagnosis and Treatment of Osteosarcoma"],"pagination":["893-905"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7893995"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112(2)"],"pubmed_abstract":["Mounting research papers have suggested that long non-coding RNAs (lncRNAs) elicit important functions in the progression of osteosarcoma (OS). This study focused on the role of TNK2-AS1 in OS. TNK2-AS1 was powerfully expressed in OS tissues and cell lines. In addition, TNK2-AS1 downregulation inhibited proliferative, migratory, and invasive capacities while promoting apoptosis in OS cells. miR-4319 was removed by TNK2-AS1 and therefore TNK2-AS1 elevated WDR1 expression in OS cells. miR-4319 had an inhibitory influence on OS progression, while WDR1 was a contributor to OS progression. Rescue assays certified that TNK2-AS1 promoted malignant phenotypes in vitro and the growth in vivo of OS cells by upregulating WDR1. In depth, we found that YY1 accelerated the transcription of TNK2-AS1 in O"],"journal":["Cancer science"],"pubmed_title":["TNK2-AS1 upregulated by YY1 boosts the course of osteosarcoma through targeting miR-4319/WDR1."],"pmcid":["PMC7893995"],"funding_grant_id":["182102410001","2018.1-2019.12"],"pubmed_authors":["Hou J","Yan Q","Du X","Yao W"],"additional_accession":[]},"is_claimable":false,"name":"TNK2-AS1 upregulated by YY1 boosts the course of osteosarcoma through targeting miR-4319/WDR1.","description":"Mounting research papers have suggested that long non-coding RNAs (lncRNAs) elicit important functions in the progression of osteosarcoma (OS). This study focused on the role of TNK2-AS1 in OS. TNK2-AS1 was powerfully expressed in OS tissues and cell lines. In addition, TNK2-AS1 downregulation inhibited proliferative, migratory, and invasive capacities while promoting apoptosis in OS cells. miR-4319 was removed by TNK2-AS1 and therefore TNK2-AS1 elevated WDR1 expression in OS cells. miR-4319 had an inhibitory influence on OS progression, while WDR1 was a contributor to OS progression. Rescue assays certified that TNK2-AS1 promoted malignant phenotypes in vitro and the growth in vivo of OS cells by upregulating WDR1. In depth, we found that YY1 accelerated the transcription of TNK2-AS1 in O","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2026-05-09T08:55:50.638Z","creation":"2021-03-05T09:11:47Z"},"accession":"S-EPMC7893995","cross_references":{"pubmed":["33164271"],"doi":["10.1111/cas.14727"]}}