{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ishikawa M"],"funding":["Diabetes Australia Research Trust","National Health and Medical Research Council","Australian Research Council"],"pagination":["759-775"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7894545"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["73(2)"],"pubmed_abstract":["<h4>Background and aims</h4>Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 mice that express different forms of the GH receptor (GHR) with deletions in key signaling domains.<h4>Approach and results</h4>PHx was performed on C57BL/6 mice lacking GHR (Ghr<sup>-/-</sup> ), disabled for all GH-dependent Janus kinase 2 signaling (Box1<sup>-/-</sup> ), or lacking only GH-dependent signal transducer and activator of transcription 5 (STAT5) signaling (Ghr391<sup>-/-</sup> ), and wild-type littermates. C57BL/6 Ghr<sup>-/-</sup> mice showed striking mortality within 48 hours after PHx, whereas Box1<sup>-/-</sup> or Ghr391<sup>-/-</sup> mice survived with normal liver regeneration. Ghr<sup>-/-</sup> mortality was associ"],"journal":["Hepatology (Baltimore, Md.)"],"pubmed_title":["Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2-Bl/HLA-G."],"pmcid":["PMC7894545"],"funding_grant_id":["APP1025094","Centre of Excellence in Convergent Bio‐Nano Scienc","APP1156489","APP1025082","APP1124026","postdoctoral fellowship"],"pubmed_authors":["Ishikawa M","Rossjohn J","Chhabra Y","Tunny KA","Ho KKY","Brooks AJ","Medina J","Fernandez-Rojo MA","Parton RG","Minami S","Chikani V","Waters MJ","Ramm GA","Vivian JP"],"additional_accession":[]},"is_claimable":false,"name":"Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2-Bl/HLA-G.","description":"<h4>Background and aims</h4>Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 mice that express different forms of the GH receptor (GHR) with deletions in key signaling domains.<h4>Approach and results</h4>PHx was performed on C57BL/6 mice lacking GHR (Ghr<sup>-/-</sup> ), disabled for all GH-dependent Janus kinase 2 signaling (Box1<sup>-/-</sup> ), or lacking only GH-dependent signal transducer and activator of transcription 5 (STAT5) signaling (Ghr391<sup>-/-</sup> ), and wild-type littermates. C57BL/6 Ghr<sup>-/-</sup> mice showed striking mortality within 48 hours after PHx, whereas Box1<sup>-/-</sup> or Ghr391<sup>-/-</sup> mice survived with normal liver regeneration. Ghr<sup>-/-</sup> mortality was associ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2026-05-08T15:20:06.634Z","creation":"2021-03-05T08:58:47Z"},"accession":"S-EPMC7894545","cross_references":{"pubmed":["32342533"],"doi":["10.1002/hep.31297"]}}