biostudies-literatureIshikawa MDiabetes Australia Research TrustNational Health and Medical Research CouncilAustralian Research Council759-775https://www.ebi.ac.uk/biostudies/studies/S-EPMC7894545biostudies-literatureUnknown73(2)<h4>Background and aims</h4>Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 mice that express different forms of the GH receptor (GHR) with deletions in key signaling domains.<h4>Approach and results</h4>PHx was performed on C57BL/6 mice lacking GHR (Ghr^-/- ), disabled for all GH-dependent Janus kinase 2 signaling (Box1^-/- ), or lacking only GH-dependent signal transducer and activator of transcription 5 (STAT5) signaling (Ghr391^-/- ), and wild-type littermates. C57BL/6 Ghr^-/- mice showed striking mortality within 48 hours after PHx, whereas Box1^-/- or Ghr391^-/- mice survived with normal liver regeneration. Ghr^-/- mortality was associHepatology (Baltimore, Md.)Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2-Bl/HLA-G.PMC7894545APP1025094Centre of Excellence in Convergent Bio‐Nano SciencAPP1156489APP1025082APP1124026postdoctoral fellowshipIshikawa MRossjohn JChhabra YTunny KAHo KKYBrooks AJMedina JFernandez-Rojo MAParton RGMinami SChikani VWaters MJRamm GAVivian JPfalseGrowth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2-Bl/HLA-G.<h4>Background and aims</h4>Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 mice that express different forms of the GH receptor (GHR) with deletions in key signaling domains.<h4>Approach and results</h4>PHx was performed on C57BL/6 mice lacking GHR (Ghr^-/- ), disabled for all GH-dependent Janus kinase 2 signaling (Box1^-/- ), or lacking only GH-dependent signal transducer and activator of transcription 5 (STAT5) signaling (Ghr391^-/- ), and wild-type littermates. C57BL/6 Ghr^-/- mice showed striking mortality within 48 hours after PHx, whereas Box1^-/- or Ghr391^-/- mice survived with normal liver regeneration. Ghr^-/- mortality was associ2021-01-01T00:00:00Z2021 Feb2026-05-08T15:20:06.634Z2021-03-05T08:58:47ZS-EPMC78945453234253310.1002/hep.31297