biostudies-literatureUnknown479(3)Collier CD<h4>Background</h4>Most cancer centers prefer preoperative radiation therapy (preRT) over postoperative therapy to treat soft-tissue sarcoma (STS) to limit long-term fibrosis, joint stiffness, and edema. Surgery is often delayed after preRT to allow for tissue recovery and to reduce wound complications. However, the association between the time interval between preRT and surgery and survival is unknown.<h4>Questions/purposes</h4>(1) What factors are associated with the preRT-surgery interval in patients with STS? (2) Is the preRT-surgery interval associated with overall survival?<h4>Methods</h4>The National Cancer Database, a nationwide registry that includes 70% of all new cancers in the United States with 90% follow-up, was reviewed to identify 6378 patients who underwent preRT and surgiClinical orthopaedics and related research506-517https://www.ebi.ac.uk/biostudies/studies/S-EPMC7899587biostudies-literatureThe Interval Between Preoperative Radiation and Surgery Is Not Associated with Overall Survival for Soft-tissue Sarcomas: An Analysis of the National Cancer Database.PMC7899587Liu RWCollier CDKim CYGetty PJfalseThe Interval Between Preoperative Radiation and Surgery Is Not Associated with Overall Survival for Soft-tissue Sarcomas: An Analysis of the National Cancer Database.<h4>Background</h4>Most cancer centers prefer preoperative radiation therapy (preRT) over postoperative therapy to treat soft-tissue sarcoma (STS) to limit long-term fibrosis, joint stiffness, and edema. Surgery is often delayed after preRT to allow for tissue recovery and to reduce wound complications. However, the association between the time interval between preRT and surgery and survival is unknown.<h4>Questions/purposes</h4>(1) What factors are associated with the preRT-surgery interval in patients with STS? (2) Is the preRT-surgery interval associated with overall survival?<h4>Methods</h4>The National Cancer Database, a nationwide registry that includes 70% of all new cancers in the United States with 90% follow-up, was reviewed to identify 6378 patients who underwent preRT and surgi2021-01-01T00:00:00Z2021 Mar2025-04-20T03:42:44.144Z2025-04-20T03:42:44.144ZS-EPMC78995873240100210.1097/corr.000000000000128710.1097/CORR.0000000000001287