biostudies-literatureUnknown100(2)Tang X<h4>Background</h4>There is still no clinical evidence available to support or to oppose corticosteroid treatment for coronavirus disease 2019 (COVID-19) pneumonia.<h4>Objective</h4>To investigate the efficacy and safety of corticosteroid given to the hospitalized patients with COVID-19 pneumonia.<h4>Methods</h4>This was a prospective, multicenter, single-blind, randomized control trial. Adult patients with COVID-19 pneumonia who were admitted to the general ward were randomly assigned to either receive methylprednisolone or not for 7 days. The primary end point was the incidence of clinical deterioration 14 days after randomization.<h4>Results</h4>We terminated this trial early because the number of patients with COVID-19 pneumonia in all the centers decreased in late March. Finally, a toRespiration; international review of thoracic diseases116-126https://www.ebi.ac.uk/biostudies/studies/S-EPMC7900459biostudies-literatureEarly Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control Trial.PMC7900459Liu LMChen JWSun BJin RHNi JXLi YLSu JZhao YHe XLShi HZZhang JYFeng YMZhang JXXie JZhang JCHu KWang WWu XZDing ZTang XfalseEarly Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control Trial.<h4>Background</h4>There is still no clinical evidence available to support or to oppose corticosteroid treatment for coronavirus disease 2019 (COVID-19) pneumonia.<h4>Objective</h4>To investigate the efficacy and safety of corticosteroid given to the hospitalized patients with COVID-19 pneumonia.<h4>Methods</h4>This was a prospective, multicenter, single-blind, randomized control trial. Adult patients with COVID-19 pneumonia who were admitted to the general ward were randomly assigned to either receive methylprednisolone or not for 7 days. The primary end point was the incidence of clinical deterioration 14 days after randomization.<h4>Results</h4>We terminated this trial early because the number of patients with COVID-19 pneumonia in all the centers decreased in late March. Finally, a to2021-01-01T00:00:00Z20212025-06-01T01:56:51.069Z2021-02-28T08:19:13ZS-EPMC79004593348649610.1159/000512063