{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["E GX"],"funding":["Fundamental Research Funds for the Central Universities","Chongqing Research Program of Basic Research and Frontier Technology","National Natural Science Foundation of China"],"pagination":["616743"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7901718"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["<b>Background:</b> Polled intersex syndrome (PIS) leads to reproductive disorders in goats and exerts a heavy influence on goat breeding. Since 2001, the core variant of an 11.7 kb deletion at ~129 Mb on chromosome 1 (CHI1) has been widely used as a genetic diagnostic criterion. In 2020, a ~0.48 Mb insertion within the PIS deletion was identified by sequencing in XX intersex goats. However, the suitability of this variation for the diagnosis of intersex goats worldwide and its further molecular genetic mechanism need to be clarified. <b>Results:</b> The whole-genome selective sweep of intersex goats from China was performed with whole-genome next-generation sequencing technology for large sample populations and a case-control study on interbreeds. A series of candidate genes related to the"],"journal":["Frontiers in genetics"],"pubmed_title":["Identification of a Goat Intersexuality-Associated Novel Variant Through Genome-Wide Resequencing and Hi-C."],"pmcid":["PMC7901718"],"funding_grant_id":["cstc2018jcyjAX0153","31172195","XDJK2018B014"],"pubmed_authors":["Li LH","Zhang JH","Zhao YJ","Li XL","Zhou DK","Zhou RY","Yang BG","Duan XH","Zeng Y","Zheng ZQ","Jiang Y","Huang YF","Ma YH","He YM","E GX","Jiang XP","Chu MX","Na RS","Nai WH","Gao HJ","Hong QH","Han YG"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a Goat Intersexuality-Associated Novel Variant Through Genome-Wide Resequencing and Hi-C.","description":"<b>Background:</b> Polled intersex syndrome (PIS) leads to reproductive disorders in goats and exerts a heavy influence on goat breeding. Since 2001, the core variant of an 11.7 kb deletion at ~129 Mb on chromosome 1 (CHI1) has been widely used as a genetic diagnostic criterion. In 2020, a ~0.48 Mb insertion within the PIS deletion was identified by sequencing in XX intersex goats. However, the suitability of this variation for the diagnosis of intersex goats worldwide and its further molecular genetic mechanism need to be clarified. <b>Results:</b> The whole-genome selective sweep of intersex goats from China was performed with whole-genome next-generation sequencing technology for large sample populations and a case-control study on interbreeds. A series of candidate genes related to the","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-30T17:05:36.755Z","creation":"2021-02-26T08:17:23Z"},"accession":"S-EPMC7901718","cross_references":{"pubmed":["33633772"],"doi":["10.3389/fgene.2020.616743"]}}