{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Filippelli M"],"pubmed_abstract":["<b>Purpose:</b> To determine the levels of pro-inflammatory cytokines and soluble mediators (TNF-α, IL6, IL2, and PDGF-AB) in 28 vitreous biopsies taken from patients with proliferative diabetic retinopathy (PDR) and treated with increasing doses of curcumin (0. 5 and 1 μM), with or without homotaurine (100 μM) and vitamin D3 (50 nM). <b>Materials and Methods:</b> ELISA tests were performed on the supernatants from 28 vitreous biopsies that were incubated with bioactive molecules at 37°C for 20 h. The concentration of the soluble mediators was calculated from a calibration curve and expressed in pg/mL. Shapiro-Wilk test was used to verify the normality of distribution of the residuals. Continuous variables among groups were compared using the General Linear Model (GLM). Homoscedasticity wa"],"journal":["Frontiers in neurology"],"pagination":["592274"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7901953"],"repository":["biostudies-literature"],"pubmed_title":["Anti-inflammatory Effect of Curcumin, Homotaurine, and Vitamin D3 on Human Vitreous in Patients With Diabetic Retinopathy."],"pmcid":["PMC7901953"],"pubmed_authors":["Vito P","Ventre L","Campagna G","dell'Omo R","Filippelli M","Bartollino S","Zotti T","Rinaldi M","Costagliola C"],"additional_accession":[]},"is_claimable":false,"name":"Anti-inflammatory Effect of Curcumin, Homotaurine, and Vitamin D3 on Human Vitreous in Patients With Diabetic Retinopathy.","description":"<b>Purpose:</b> To determine the levels of pro-inflammatory cytokines and soluble mediators (TNF-α, IL6, IL2, and PDGF-AB) in 28 vitreous biopsies taken from patients with proliferative diabetic retinopathy (PDR) and treated with increasing doses of curcumin (0. 5 and 1 μM), with or without homotaurine (100 μM) and vitamin D3 (50 nM). <b>Materials and Methods:</b> ELISA tests were performed on the supernatants from 28 vitreous biopsies that were incubated with bioactive molecules at 37°C for 20 h. The concentration of the soluble mediators was calculated from a calibration curve and expressed in pg/mL. Shapiro-Wilk test was used to verify the normality of distribution of the residuals. Continuous variables among groups were compared using the General Linear Model (GLM). Homoscedasticity wa","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-05-29T20:31:58.173Z","creation":"2025-05-29T20:31:58.173Z"},"accession":"S-EPMC7901953","cross_references":{"pubmed":["33633656"],"doi":["10.3389/fneur.2020.592274"]}}