biostudies-literatureUnknown9Boazak EMGeorgia Research AllianceNational Institutes of HealthThe biomechanical properties of the cornea and sclera are important in the onset and progression of multiple ocular pathologies and vary substantially between individuals, yet the source of this variation remains unknown. Here we identify genes putatively regulating corneoscleral biomechanical tissue properties by conducting high-fidelity ocular compliance measurements across the BXD recombinant inbred mouse set and performing quantitative trait analysis. We find seven cis-eQTLs and non-synonymous SNPs associating with ocular compliance, and show by RT-qPCR and immunolabeling that only two of the candidate genes, <i>Smarce1</i> and <i>Tns4</i>, showed significant expression in corneal and scleral tissues. Both have mechanistic potential to influence the development and/or regulation of tisFrontiers in bioengineering and biotechnology596154https://www.ebi.ac.uk/biostudies/studies/S-EPMC7902041biostudies-literature<i>Smarce1</i> and <i>Tensin 4</i> Are Putative Modulators of Corneoscleral Stiffness.PMC7902041Overby DREthier CRBoazak EMChu CMGeisert EEToporek AMWang JKing RSherwood JMfalse<i>Smarce1</i> and <i>Tensin 4</i> Are Putative Modulators of Corneoscleral Stiffness.The biomechanical properties of the cornea and sclera are important in the onset and progression of multiple ocular pathologies and vary substantially between individuals, yet the source of this variation remains unknown. Here we identify genes putatively regulating corneoscleral biomechanical tissue properties by conducting high-fidelity ocular compliance measurements across the BXD recombinant inbred mouse set and performing quantitative trait analysis. We find seven cis-eQTLs and non-synonymous SNPs associating with ocular compliance, and show by RT-qPCR and immunolabeling that only two of the candidate genes, <i>Smarce1</i> and <i>Tns4</i>, showed significant expression in corneal and scleral tissues. Both have mechanistic potential to influence the development and/or regulation of tis2021-01-01T00:00:00Z20212026-05-08T13:42:39.287Z2025-05-29T21:47:00.303ZS-EPMC79020413363408110.3389/fbioe.2021.596154