biostudies-literatureUnknown11(1)Alberro AThe improvement of life quality and medical advances has resulted in increased life expectancy. Despite this, health status commonly worsens in the last years of life. Frailty is an intermediate and reversible state that often precedes dependency and therefore, its identification may be essential to prevent dependency. However, there is no consensus on the best tools to identify frailty. In this sense, diverse molecules have been proposed as potential biomarkers. Some investigations pointed to an increased chronic inflammation or inflammaging with frailty, while others did not report such differences. In this work, we evaluated the circulating concentration of the inflammaging markers in adults and older adults (aged over 70 years) by ELISA and Luminex techniques. The Barthel Index was appScientific reports4358https://www.ebi.ac.uk/biostudies/studies/S-EPMC7902838biostudies-literatureInflammaging markers characteristic of advanced age show similar levels with frailty and dependency.PMC7902838Alberro ASaenz-Cuesta MOtaegui DIribarren-Lopez AMatheu AVergara IfalseInflammaging markers characteristic of advanced age show similar levels with frailty and dependency.The improvement of life quality and medical advances has resulted in increased life expectancy. Despite this, health status commonly worsens in the last years of life. Frailty is an intermediate and reversible state that often precedes dependency and therefore, its identification may be essential to prevent dependency. However, there is no consensus on the best tools to identify frailty. In this sense, diverse molecules have been proposed as potential biomarkers. Some investigations pointed to an increased chronic inflammation or inflammaging with frailty, while others did not report such differences. In this work, we evaluated the circulating concentration of the inflammaging markers in adults and older adults (aged over 70 years) by ELISA and Luminex techniques. The Barthel Index was app2021-01-01T00:00:00Z2021 Feb2025-04-26T05:53:42.971Z2021-02-28T08:15:18ZS-EPMC79028383362305710.1038/s41598-021-83991-7