biostudies-literatureSubhedar NVMedical Research CouncilNational Institute for Health Research (NIHR)e000897https://www.ebi.ac.uk/biostudies/studies/S-EPMC7903123biostudies-literatureUnknown5(1)<h4>Objective</h4>To describe temporal changes in inhaled nitric oxide (iNO) use in English neonatal units between 2010 and 2015.<h4>Design</h4>Retrospective analysis using data extracted from the National Neonatal Research Database.<h4>Setting</h4>All National Health Service neonatal units in England.<h4>Patients</h4>Infants of all gestational ages born 2010-2015 admitted to a neonatal unit and received intensive care.<h4>Main outcome measures</h4>Proportion of infants who received iNO; age at initiation and duration of iNO use.<h4>Results</h4>4.9% (6346/129 883) of infants received iNO; 31% (1959/6346) were born <29 weeks, 18% (1152/6346) 29-33 weeks and 51% (3235/6346)>34 weeks of gestation. Between epoch 1 (2010-2011) and epoch 3 (2014-2015), there was (1) an increase in the proportionBMJ paediatrics openIncrease in the use of inhaled nitric oxide in neonatal intensive care units in England: a retrospective population study.PMC7903123NIHR300617MR/N008405/1Seagrave CSandhu SZengeya SObi OOliver CBalal SBen Obi PAShephard RWickham THalpert PJames MBanjoko OBrooke NMaddock NCusack JBontea ABaird JMartin PDixon HEmery FKapur JMurthy VGarbash MSanghavi RJain NNicholl RKendall GJain MBabirecki MLeith WAbu-Harb MVasu VNash MGibson DTheron MPai VRewitzky GWhincup GBirch JRekha SFoo AAdiotomre PAucharaz KLee GVamvakiti KSeal SRhodes SNath PFedee JOgundiya ASalgia SJawad SSchwarz KChang JZipitis CMcIntyre JSivashankar SHolman JAung YMGupta RWebb DKhashu MMunyard PMittal AGupta SGupta VBate TAdams EMannan KHarry LOlabi ABrearey SMattara SKnight CDeketelaere AHalpern LNegrine RSettle PPaul NAung YPaul SBhat RCairns PGupta AGroves CAmess PGupta CBattersby CHassan ASurana PKrishnamurthy GRWinder LAbdul Khader KAthiraman NKefas JSelter MBrennan NReddy CMiall LWinckworth LEvans IMack KEaton MAllwood AReddy AOughham KChuang SLSullivan CTyszcuzk LHeal CWong LMD'Amore AHasib ALal MMisra IDeshpande ESJones SAbdul-Malik BJohnson MBirdThiagarajan PDewhurst CHartung RGaili HRawlingson CBastani PAladangady NHuddy CDyke MGarr RHulse EKamalanathan AAli IWhitehead GDale ANarayanan SMuogbo DGale CPandey PGrosdenier MKamath PAnderson JKisat HKumar HKairamkonda VWardle SAmbadkarSubhedar NVMcDevitt KEdi-Osagie NUK Neonatal CollaborativefalseIncrease in the use of inhaled nitric oxide in neonatal intensive care units in England: a retrospective population study.<h4>Objective</h4>To describe temporal changes in inhaled nitric oxide (iNO) use in English neonatal units between 2010 and 2015.<h4>Design</h4>Retrospective analysis using data extracted from the National Neonatal Research Database.<h4>Setting</h4>All National Health Service neonatal units in England.<h4>Patients</h4>Infants of all gestational ages born 2010-2015 admitted to a neonatal unit and received intensive care.<h4>Main outcome measures</h4>Proportion of infants who received iNO; age at initiation and duration of iNO use.<h4>Results</h4>4.9% (6346/129 883) of infants received iNO; 31% (1959/6346) were born <29 weeks, 18% (1152/6346) 29-33 weeks and 51% (3235/6346)>34 weeks of gestation. Between epoch 1 (2010-2011) and epoch 3 (2014-2015), there was (1) an increase in the proportion2021-01-01T00:00:00Z20212025-04-22T08:16:10.272Z2021-03-12T08:18:37ZS-EPMC79031233370550010.1136/bmjpo-2020-000897