biostudies-literatureUnknown325(8)Sevransky JE<h4>Importance</h4>Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.<h4>Objective</h4>To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis.<h4>Design, setting, and participants</h4>Multicenter, randomized, double-blind, adaptive-sample-size, placebo-controlled trial conducted in adult patients with sepsis-induced respiratory and/or cardiovascular dysfunction. Participants were enrolled in the emergency departments or intensive care units at 43 hospitals in the United States between August 2018 and July 2019. After JAMA742-750https://www.ebi.ac.uk/biostudies/studies/S-EPMC7903252biostudies-literatureEffect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.PMC7903252Pinkert VDouglas ILyle CChang SYHilz KViele KMcBryde BVisweswaran AEncinas ANugent KLHastings AGajic ODickson LHall GBledsoe JKostelecky NJanz DRMcSparron JSiner JMarlin JSBarksdale AMiller SHurst GBuchman TGEyzaguirre LMHinson JSPlante AGorder KYoungquist STExline MLopez BWoodburn RHall AHaukoos JKruse DQuinn JHudock KNomura JSchwegler DHenson MJayaprakash NClare JGill JCase CGoodwin ADavis JGill RHowell MBaram MGummadi SReimer HVICTAS InvestigatorsApplegate DArmbruster BFinck LKarow SHypes CPastores SMKrol OVonderhaar DFlores LJones LHaq ESill JSteingrub JPflaum JGrady AOropello JNarron KRenzi NWilkerson RGDeWilde CAboodi MGuirgis FKea BGreenwood JCMulrow MCampbell ESGong MNLimkakeng ASweeney KMoore BLEly EWRicketts EPBartz RZhang ZWira CDaw AMoss MDuggal AFiles DCPeltan ITerndrup TThornton-Thompson SWilson JSevransky JELewis RJHays MSemler MWWilkins EKelen GDBrown SMSelf WHMontgomery QPolito CCDavidov EMeyer NJGentile NCook AHooper MHNwosu SOakes JKashyap RLyons MHager DNVanmeter DGibbs KClements CMMann RGinde AHope ATrent SQadir NPuskarich MAMcCurdy MTMitchell KDanley SHendrickson ACupelo APrice KBlack LMcDonough KMosier JMBernard GRLasko KTam APrekker MERudolph CCGravitz SMcKeehan JHarris ESRice TWGardner-Gray JHiggins CPannu SSanfilippo FGoyal MHanna SCo ILoVecchio FMoriarty TJaehne AKBeach DBrokowski CLevine MAKalin DPark PIttner CHiller TAhmad YSpainhour CLevitt JHite RDBusse LWNegrin LBeutler RMiddleton EARivers ERothman REMcGlothlin AChen JTGaieski DFLindsell CJWright DWMartin GSCoopersmith CMMarchetti NShaz DJFowler AABarrett MHyzy RZaaqoq ARomaine CKhan AKnox JNguyen KSmithline HSmith LStuder AMcBride MBrown KBelsky JRobart EMace SEQuiroga PfalseEffect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.<h4>Importance</h4>Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.<h4>Objective</h4>To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis.<h4>Design, setting, and participants</h4>Multicenter, randomized, double-blind, adaptive-sample-size, placebo-controlled trial conducted in adult patients with sepsis-induced respiratory and/or cardiovascular dysfunction. Participants were enrolled in the emergency departments or intensive care units at 43 hospitals in the United States between August 2018 and July 2019. After 2021-01-01T00:00:00Z2021 Feb2026-05-01T11:29:13.617Z2022-02-11T11:13:47.315ZS-EPMC79032523362040510.1001/jama.2020.24505