{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["34(2)"],"submitter":["Kamal F"],"pubmed_abstract":["<h4>Background</h4>Heller myotomy (HM) is an established treatment for achalasia but can fail in up to 10-20% of patients. Peroral endoscopic myotomy (POEM) may be an appropriate treatment for patients with failed HM.<h4>Methods</h4>We searched several databases to identify non-comparative studies evaluating the efficacy and/or safety of POEM after failed HM and comparative studies comparing the efficacy and/or safety of POEM in patients with and without prior HM. Outcomes assessed included clinical success, technical success, adverse events, post-treatment gastroesophageal reflux disease (GERD), and presence of esophagitis on endoscopy. We calculated weighted pooled rates with 95% confidence intervals (CI) for all outcomes in patients undergoing POEM with prior HM. We calculated pooled od"],"journal":["Annals of gastroenterology"],"pagination":["155-163"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7903572"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy and safety of peroral endoscopic myotomy in the management of recurrent achalasia after failed Heller myotomy: a systematic review and meta-analysis."],"pmcid":["PMC7903572"],"pubmed_authors":["Marella HK","Heda RP","Sharma S","Tombazzi C","Khan Z","Adler DG","Ismail MK","Kamal F","Lee-Smith W","Tariq R","Howden CW","Khan MA","Sharaiha RZ","McDonough S"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy and safety of peroral endoscopic myotomy in the management of recurrent achalasia after failed Heller myotomy: a systematic review and meta-analysis.","description":"<h4>Background</h4>Heller myotomy (HM) is an established treatment for achalasia but can fail in up to 10-20% of patients. Peroral endoscopic myotomy (POEM) may be an appropriate treatment for patients with failed HM.<h4>Methods</h4>We searched several databases to identify non-comparative studies evaluating the efficacy and/or safety of POEM after failed HM and comparative studies comparing the efficacy and/or safety of POEM in patients with and without prior HM. Outcomes assessed included clinical success, technical success, adverse events, post-treatment gastroesophageal reflux disease (GERD), and presence of esophagitis on endoscopy. We calculated weighted pooled rates with 95% confidence intervals (CI) for all outcomes in patients undergoing POEM with prior HM. We calculated pooled od","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-26T05:59:39.086Z","creation":"2021-03-05T08:08:50Z"},"accession":"S-EPMC7903572","cross_references":{"pubmed":["33654353"],"doi":["10.20524/aog.2020.0563"]}}