{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Acun A"],"funding":["NIDDK NIH HHS","National Institutes of Health","Shriners Hospitals for Children"],"pagination":["120689"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7906943"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["270"],"pubmed_abstract":["The only treatment available for end stage liver diseases is orthotopic liver transplantation. Although there is a big donor scarcity, many donor livers are discarded as they do not qualify for transplantation. Alternatively, decellularization of discarded livers can potentially render them transplantable upon recellularization and functional testing. The success of this approach will heavily depend on the quality of decellularized scaffolds which might show variability due to factors including age. Here we assessed the age-dependent differences in liver extracellular matrix (ECM) using rat and human livers. We show that the liver matrix has higher collagen and glycosaminoglycan content and a lower growth factor content with age. Importantly, these changes lead to deterioration in primary "],"journal":["Biomaterials"],"pubmed_title":["Liver donor age affects hepatocyte function through age-dependent changes in decellularized liver matrix."],"pmcid":["PMC7906943"],"funding_grant_id":["R01 DK084053","R00 DK088962"],"pubmed_authors":["Yeh H","Yarmush ML","Acun A","Uygun K","Uygun BE","Oganesyan R"],"additional_accession":[]},"is_claimable":false,"name":"Liver donor age affects hepatocyte function through age-dependent changes in decellularized liver matrix.","description":"The only treatment available for end stage liver diseases is orthotopic liver transplantation. Although there is a big donor scarcity, many donor livers are discarded as they do not qualify for transplantation. Alternatively, decellularization of discarded livers can potentially render them transplantable upon recellularization and functional testing. The success of this approach will heavily depend on the quality of decellularized scaffolds which might show variability due to factors including age. Here we assessed the age-dependent differences in liver extracellular matrix (ECM) using rat and human livers. We show that the liver matrix has higher collagen and glycosaminoglycan content and a lower growth factor content with age. Importantly, these changes lead to deterioration in primary ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T19:53:41.714Z","creation":"2025-04-04T19:53:41.714Z"},"accession":"S-EPMC7906943","cross_references":{"pubmed":["33524812"],"doi":["10.1016/j.biomaterials.2021.120689"]}}