{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Blumenthaler AN"],"funding":["Holly Clegg Gastric Cancer Research Fund","NCI NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["911-922"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7906958"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["123(4)"],"pubmed_abstract":["<h4>Background and objectives</h4>We sought to evaluate the impact of lymphovascular invasion (LVI) and perineural invasion (PNI) on survival outcomes in gastric cancer patients treated with preoperative therapy.<h4>Methods</h4>Patients with gastric cancer treated with preoperative therapy and potentially curative resection were stratified according to the presence of LVI, PNI, or both. Kaplan-Meier and Cox regression analyses were used to evaluate the impact on overall survival (OS) and disease-free survival (DFS).<h4>Results</h4>The study included 281 patients, of whom 93 (33%) had LVI, 69 (25%) had PNI, 51 (18%) had both LVI and PNI, and 170 (61%) had neither. LVI and PNI were each associated with higher ypT and ypN categories and more positive lymph nodes (all p < .001), associations t"],"journal":["Journal of surgical oncology"],"pubmed_title":["Concurrent lymphovascular and perineural invasion after preoperative therapy for gastric adenocarcinoma is associated with decreased survival."],"pmcid":["PMC7906958"],"funding_grant_id":["P30 CA016672","T32 CA009599","No Stomach For Cancer Award for Gastric Cancer Res"],"pubmed_authors":["Ajani JA","Badgwell BD","Ikoma N","Newhook TE","Minsky BD","Mansfield PF","Estrella JS","Das P","Blum Murphy M","Blumenthaler AN"],"additional_accession":[]},"is_claimable":false,"name":"Concurrent lymphovascular and perineural invasion after preoperative therapy for gastric adenocarcinoma is associated with decreased survival.","description":"<h4>Background and objectives</h4>We sought to evaluate the impact of lymphovascular invasion (LVI) and perineural invasion (PNI) on survival outcomes in gastric cancer patients treated with preoperative therapy.<h4>Methods</h4>Patients with gastric cancer treated with preoperative therapy and potentially curative resection were stratified according to the presence of LVI, PNI, or both. Kaplan-Meier and Cox regression analyses were used to evaluate the impact on overall survival (OS) and disease-free survival (DFS).<h4>Results</h4>The study included 281 patients, of whom 93 (33%) had LVI, 69 (25%) had PNI, 51 (18%) had both LVI and PNI, and 170 (61%) had neither. LVI and PNI were each associated with higher ypT and ypN categories and more positive lymph nodes (all p < .001), associations t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T19:53:49.586Z","creation":"2025-04-04T19:53:49.586Z"},"accession":"S-EPMC7906958","cross_references":{"pubmed":["33400838"],"doi":["10.1002/jso.26367"]}}